[PDF][PDF] Epithelial-mesenchymal plasticity in cancer progression and metastasis

W Lu, Y Kang - Developmental cell, 2019 - cell.com
Epithelial-to-mesenchymal transition (EMT) and its reversed process, mesenchymal-to-
epithelial transition (MET), are fundamental processes in embryonic development and tissue …

Non-redundant functions of EMT transcription factors

MP Stemmler, RL Eccles, S Brabletz, T Brabletz - Nature cell biology, 2019 - nature.com
Epithelial–mesenchymal transition (EMT) is a crucial embryonic programme that is executed
by various EMT transcription factors (EMT-TFs) and is aberrantly activated in cancer and …

[PDF][PDF] Epithelial plasticity, epithelial-mesenchymal transition, and the TGF-β family

Y Katsuno, R Derynck - Developmental cell, 2021 - cell.com
Epithelial cells repress epithelial characteristics and elaborate mesenchymal characteristics
to migrate to other locations and acquire new properties. Epithelial plasticity responses are …

Epithelial–mesenchymal transition: The history, regulatory mechanism, and cancer therapeutic opportunities

Z Huang, Z Zhang, C Zhou, L Liu, C Huang - MedComm, 2022 - Wiley Online Library
Epithelial–mesenchymal transition (EMT) is a program wherein epithelial cells lose their
junctions and polarity while acquiring mesenchymal properties and invasive ability …

Broad applicability of a streamlined ethyl cinnamate-based clearing procedure

W Masselink, D Reumann, P Murawala… - …, 2019 - journals.biologists.com
Turbidity and opaqueness are inherent properties of tissues that limit the capacity to acquire
microscopic images through large tissues. Creating a uniform refractive index, known as …

Pitx2 patterns an accelerator-brake mechanical feedback through latent TGFβ to rotate the gut

BD Sanketi, N Zuela-Sopilniak, E Bundschuh, S Gopal… - Science, 2022 - science.org
The vertebrate intestine forms by asymmetric gut rotation and elongation, and errors cause
lethal obstructions in human infants. Rotation begins with tissue deformation of the dorsal …

Integrative genomic analyses identify candidate causal genes for calcific aortic valve stenosis involving tissue-specific regulation

S Thériault, Z Li, E Abner, J Luan… - Nature …, 2024 - nature.com
There is currently no medical therapy to prevent calcific aortic valve stenosis (CAVS). Multi-
omics approaches could lead to the identification of novel molecular targets. Here, we …

Left-right asymmetry in heart development and disease: forming the right loop

A Desgrange, JF Le Garrec, SM Meilhac - Development, 2018 - journals.biologists.com
Extensive studies have shown how bilateral symmetry of the vertebrate embryo is broken
during early development, resulting in a molecular left-right bias in the mesoderm. However …

Prrx1b restricts fibrosis and promotes Nrg1-dependent cardiomyocyte proliferation during zebrafish heart regeneration

DEM de Bakker, M Bouwman, E Dronkers… - …, 2021 - journals.biologists.com
Fibroblasts are activated to repair the heart following injury. Fibroblast activation in the
mammalian heart leads to a permanent fibrotic scar that impairs cardiac function. In other …

A gene regulatory network to control EMT programs in development and disease

H Fazilaty, L Rago, K Kass Youssef, OH Ocaña… - Nature …, 2019 - nature.com
Abstract The Epithelial to Mesenchymal Transition (EMT) regulates cell plasticity during
embryonic development and in disease. It is dynamically orchestrated by transcription …