Optimizing precision medicine for second-step depression treatment: a machine learning approach

J Curtiss, JW Smoller, P Pedrelli - Psychological Medicine, 2024 - cambridge.org
BackgroundLess than a third of patients with depression achieve successful remission with
standard first-step antidepressant monotherapy. The process for determining appropriate …

Post-weaning social isolated flinders sensitive line rats display bio-behavioural manifestations resistant to fluoxetine: a model of treatment-resistant depression

K Mncube, M Möller, BH Harvey - Frontiers in Psychiatry, 2021 - frontiersin.org
Treatment-resistant depression (TRD) complicates the management of major depression
(MD). The underlying biology of TRD involves interplay between genetic propensity and …

[HTML][HTML] Bio-behavioural changes in treatment-resistant socially isolated FSL rats show variable or improved response to combined fluoxetine-olanzapine versus …

K Mncube, BH Harvey - IBRO Neuroscience Reports, 2022 - Elsevier
Abstract Background Exposure of Flinders Sensitive Line (FSL) rats to post-weaning social
isolation rearing (SIR) causes depressive-and social anxiety-like symptoms resistant to, or …

[HTML][HTML] Patient and provider perspectives on the phenomenon and effective treatment of treatment-resistant depression: A grounded theory

A Bornhoff, EB Davis, J Yousey, CN Kimball… - Journal of Affective …, 2024 - Elsevier
Abstract Background Treatment-Resistant Depression (TRD) is a poorly understood but
prevalent clinical phenomenon that lacks a widely accepted definition, explanatory model, or …

[PDF][PDF] Simulating depression-like abnormal brain activity and stimulation treatment with The Virtual Brain

C Iliaens - libstore.ugent.be
Major depressive disorder is a severe mental health issue affecting many people. Previous
research found evidence for changes in functional and structural connectivity as well as …

Development and validation of an animal model of treatment-resistant depression with psychotic features

K Mncube - 2021 - repository.nwu.ac.za
Major depression (MD) affects up to 17% of the global population. While effective treatments
for MD exist, an underlying interaction between genetic propensity and chronic and/or early …

Tek atak ve tekrarlayan unipolar depresif bozuklukta hasta lenfositlerinde dna hasar ve tamir etkinliğindeki farklılıkların karşılaştırılması ve bilişsel fonksiyonlara …

MM Yıldırım - 2020 - gcris.pau.edu.tr
Major depresif bozukluk en yaygın görülen duygudurum bozukluğudur, tek atak ya da
tekrarlayan ataklarla seyredebilir. Major depresif bozukluk yaygın olarak görülmesine …

Ketamine for treatment-resistant depression

MA Gary - Nursing made Incredibly Easy, 2019 - journals.lww.com
According to the World Health Organization, more than 300 million people of all ages
around the world experience depression. The US Substance Abuse and Mental Health …

[PDF][PDF] EFECTO ANTIDEPRESIVO DE LA ESTIMULACIÓN MAGNÉTICA TRANSCRANEAL REPETITIVA EN EL MODELO ANIMAL DE ESTRÉS CRÓNICO …

JA PÉREZ - 2021 - ru.dgb.unam.mx
Se estima que más de 300 millones de personas a nivel mundial sufren de depresión. En el
caso de los pacientes con trastorno depresivo mayor (TDM), después de haber pasado por …