Peroxisomes are often dismissed as the cellular hoi polloi, relegated to cleaning up reactive
oxygen chemical debris discarded by other organelles. However, their functions extend far …

OR the past 10 years, there has been substantial progress in the field of peroxisome
biogenesis. One key to this progress has been the use of genetic approaches in a wide …

A group of cytosolic proteins are targeted to lysosomes for degradation in response to serum
withdrawal or prolonged starvation by a process termed chaperone-mediated autophagy. In …

PEX5 encodes the type-1 peroxisomal targeting signal (PTS1) receptor, one of at least 15
peroxins required for peroxisome biogenesis. Pex5p has a bimodal distribution within the …

The mechanisms by which peroxisomal membrane proteins (PMPs) are targeted to and
inserted into membranes are unknown, as are the required components. We show that …

We used the dye N-(3-triethylammoniumpropyl)-4-(p-diethylaminophenylhexatrienyl)
pyridinium dibromide (FM4-64) and a fusion protein, consisting of the green fluorescent …

▪ Abstract Fifteen years ago, we had a model of peroxisome biogenesis that involved growth
and division of preexisting peroxisomes. Today, thanks to genetically tractable model …

Subramani, Suresh. Components Involved in Peroxisome Import, Biogenesis, Proliferation,
Turnover, and Movement. Physiol. Rev. 78: 171–188, 1998.—In the decade that has …

Zellweger syndrome and related diseases are caused by defective import of peroxisomal
matrix proteins. In all previously reported Zellweger syndrome cell lines the defect could be …

At least 11 complementation groups (CGs) have been identified for the peroxisome
biogenesis disorders (PBDs) such as Zellweger syndrome, for which seven pathogenic …