Functions of the aryl hydrocarbon receptor (AHR) beyond the canonical AHR/ARNT signaling pathway

NC Sondermann, S Faßbender, F Hartung… - Biochemical …, 2023 - Elsevier
The aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor regulating
adaptive and maladaptive responses toward exogenous and endogenous signals …

Extracellular matrix regulation in physiology and in brain disease

A Soles, A Selimovic, K Sbrocco, F Ghannoum… - International journal of …, 2023 - mdpi.com
The extracellular matrix (ECM) surrounds cells in the brain, providing structural and
functional support. Emerging studies demonstrate that the ECM plays important roles during …

[HTML][HTML] Aryl hydrocarbon receptor: The master regulator of immune responses in allergic diseases

F Riaz, F Pan, P Wei - Frontiers in Immunology, 2022 - frontiersin.org
The aryl hydrocarbon receptor (AhR) is a widely studied ligand-activated cytosolic
transcriptional factor that has been associated with the initiation and progression of various …

Environmental air pollutants affecting skin functions with systemic implications

G Bocheva, RM Slominski, AT Slominski - International Journal of …, 2023 - mdpi.com
The increase in air pollution worldwide represents an environmental risk factor that has
global implications for the health of humans worldwide. The skin of billions of people is …

Apical and mechanistic effects of 6PPD-quinone on different life-stages of the fathead minnow (Pimephales promelas)

K Anderson-Bain, C Roberts, E Kohlman, X Ji… - … and Physiology Part C …, 2023 - Elsevier
Abstract N-(1, 3-dimethylbutyl)-N′-phenyl-p-phenylenediamine-quinone (6PPD-quinone) is
an emerging contaminant of concern that is generated through the environmental oxidation …

Microbiota, oxidative stress, and skin cancer: An unexpected triangle

B Azzimonti, C Ballacchino, P Zanetta, MA Cucci… - Antioxidants, 2023 - mdpi.com
Mounting evidence indicates that the microbiota, the unique combination of micro-organisms
residing in a specific environment, plays an essential role in the development of a wide …

AhR and Wnt/β-Catenin signaling pathways and their interplay

AY Grishanova, LS Klyushova… - Current Issues in …, 2023 - mdpi.com
As evolutionarily conserved signaling cascades, AhR and Wnt signaling pathways play a
critical role in the control over numerous vital embryonic and somatic processes. AhR …

Heavy metals, oxidative stress, and the role of AhR signaling

Z Kou, F Tran, W Dai - Toxicology and Applied Pharmacology, 2024 - Elsevier
Abstract The Aryl Hydrocarbon Receptor (AhR) is a ligand-activated transcriptional factor
pivotal in responding to environmental stress and maintaining cellular homeostasis …

Biomarkers of oxidative stress and inflammation in subjects with COVID-19: Characterization and prognosis of the disease

PMV Coronel, IC Pereira, DCLS Basilio… - Microbial …, 2023 - Elsevier
Abstract Coronavirus disease (COVID-19) is an acute respiratory disease caused by the
new coronavirus (SARS-CoV-2) that has spread throughout the world causing millions of …

Dioxin (-like)-Related Biological Effects through Integrated Chemical-wide and Metabolome-wide Analyses

Y Zhao, J Meijer, DI Walker, J Kim… - Environmental …, 2023 - ACS Publications
Dioxin (-like) exposures are linked to adverse health effects, including cancer. However,
metabolic alterations induced by these chemicals remain largely unknown. Beyond known …