Magnetic resonance imaging with hyperpolarized agents: methods and applications
In the past decade, hyperpolarized (HP) contrast agents have been under active
development for MRI applications to address the twin challenges of functional and …
development for MRI applications to address the twin challenges of functional and …
[HTML][HTML] Recent advances in the non-invasive assessment of fibrosis using biomarkers
AL Tatler - Current Opinion in Pharmacology, 2019 - Elsevier
Fibrosis can occur in most organs and is characterised by excessive and progressive
extracellular matrix deposition and destruction of normal tissue architecture and function. In …
extracellular matrix deposition and destruction of normal tissue architecture and function. In …
[HTML][HTML] Lysyl oxidase like 2 is increased in asthma and contributes to asthmatic airway remodelling
J Ramis, R Middlewick, F Pappalardo… - European …, 2022 - Eur Respiratory Soc
Background Airway smooth muscle (ASM) cells are fundamental to asthma pathogenesis,
influencing bronchoconstriction, airway hyperresponsiveness and airway remodelling. The …
influencing bronchoconstriction, airway hyperresponsiveness and airway remodelling. The …
Assessment of flip angle–TR equivalence for standardized dissolved‐phase imaging of the lung with hyperpolarized 129Xe MRI
Purpose To investigate the feasibility of describing the impact of any flip angle–TR
combination on the resulting distribution of the hyperpolarized xenon‐129 (HXe) dissolved …
combination on the resulting distribution of the hyperpolarized xenon‐129 (HXe) dissolved …
Investigating the impact of RF saturation‐pulse parameters on compartment‐selective gas‐phase depolarization with xenon polarization transfer contrast MRI
T Achekzai, K Ruppert, L Loza… - Magnetic resonance …, 2022 - Wiley Online Library
Purpose To demonstrate the utility of continuous‐wave (CW) saturation pulses in xenon‐
polarization transfer contrast (XTC) MRI and MRS, to investigate the selectivity of CW pulses …
polarization transfer contrast (XTC) MRI and MRS, to investigate the selectivity of CW pulses …
Electron and nuclear spin polarization in Rb-Xe spin-exchange optical hyperpolarization
Spin-exchange optical hyperpolarization of Xe 129 gas enhances the signal-to-noise ratio in
nuclear magnetic resonance experiments. The governing parameter of the Rb-Xe spin …
nuclear magnetic resonance experiments. The governing parameter of the Rb-Xe spin …
Measuring pulmonary gas exchange using compartment‐selective xenon‐polarization transfer contrast (XTC) MRI
Purpose To demonstrate the feasibility of generating red blood cell (RBC) and tissue/plasma
(TP)‐specific gas‐phase (GP) depolarization maps using xenon‐polarization transfer …
(TP)‐specific gas‐phase (GP) depolarization maps using xenon‐polarization transfer …
Differential remodeling in small and large murine airways revealed by novel whole lung airway analysis
Airway remodeling occurs in chronic asthma leading to increased airway smooth muscle
(ASM) mass and extracellular matrix (ECM) deposition. Although extensively studied in …
(ASM) mass and extracellular matrix (ECM) deposition. Although extensively studied in …
[HTML][HTML] Lung function measurements in preclinical research: What has been done and where is it headed?
Due to the close interaction of lung morphology and functions, repeatable measurements of
pulmonary function during longitudinal studies on lung pathophysiology and treatment …
pulmonary function during longitudinal studies on lung pathophysiology and treatment …
Effect of T1 relaxation on ventilation mapping using hyperpolarized 129Xe multiple breath wash‐out imaging
Purpose To investigate the effect of incorporating T1 as a function of wash‐out breath
number (T1 (n)) on estimation of fractional ventilation (r) using hyperpolarized 129Xe …
number (T1 (n)) on estimation of fractional ventilation (r) using hyperpolarized 129Xe …