The heart is vital for biological function in almost all chordates, including humans. It beats
continually throughout our life, supplying the body with oxygen and nutrients while removing …

Mechanical forces will have been omnipresent since the origin of life, and living organisms
have evolved mechanisms to sense, interpret, and respond to mechanical stimuli. The …

In many cases, the mechanical properties of a tumor are different from those of the host
tissue. Mechanical cues regulate cancer development by affecting both tumor cells and their …

Migraine is a debilitating neurological condition affecting millions of people worldwide. Until
a few years ago, preventive migraine treatments were based on molecules with pleiotropic …

Oxidative stress and immune response play an important role in the development of several
cancers, including melanoma. Ion channels are aberrantly expressed in tumour cells and …

The field of mitochondrial ion channels underwent a rapid development during the last
decade, thanks to the molecular identification of some of the nuclear-encoded organelle …

Abstract Aims Atrial Fibrillation (AF) is an arrhythmia of increasing prevalence in the aging
populations of developed countries. One of the important indicators of AF is sustained atrial …

Tumor microenvironments are often characterized by an increase in oxidative stress levels.
We studied the response to oxidative stimulation in human primary (IGR39) or metastatic …

Several tumor entities have been reported to overexpress KCa3. 1 potassium channels due
to epigenetic, transcriptional, or post-translational modifications. By modulating membrane …

Protein lipidation is one of the most common forms of posttranslational modification. This
alteration couples different lipids, such as fatty acids, phospho-and glycolipids and sterols, to …