Over the past decade, melanoma has led the field in new cancer treatments, with impressive
gains in on-treatment survival but more modest improvements in overall survival. Melanoma …

Fibroblasts, the principal cell type of connective tissue, secrete extracellular matrix
components during tissue development, homeostasis, repair and disease. Despite this …

Cell differentiation and function are regulated across multiple layers of gene regulation,
including modulation of gene expression by changes in chromatin accessibility. However …

Dendritic cells (DCs) of the cDC2 lineage initiate allergic immunity and in the dermis are
marked by their expression of CD301b. CD301b+ dermal DCs respond to allergens …

Dermal fibroblasts exhibit considerable heterogeneity during homeostasis and in response
to injury. Defining lineage origins of reparative fibroblasts and regulatory programs that drive …

Delayed and often impaired wound healing in the elderly presents major medical and
socioeconomic challenges. A comprehensive understanding of the cellular/molecular …

Chronic, sustained exposure to stressors can profoundly affect tissue homeostasis, although
the mechanisms by which these changes occur are largely unknown. Here we report that the …

The structural properties of biomaterials play crucial roles in guiding cell behavior and
influencing immune responses against the material. We fabricated electrospun membranes …

Inflammation early in life can prime the local immune milieu of peripheral tissues, which can
cause lasting changes in immunological tone that confer disease protection or susceptibility …

Spatiotemporal regulation of the cellular transcriptome is crucial for proper protein
expression and cellular function. However, the intricate subcellular dynamics of RNA remain …