Diet and depression: exploring the biological mechanisms of action
The field of nutritional psychiatry has generated observational and efficacy data supporting a
role for healthy dietary patterns in depression onset and symptom management. To guide …
role for healthy dietary patterns in depression onset and symptom management. To guide …
Mendelian randomization: genetic anchors for causal inference in epidemiological studies
G Davey Smith, G Hemani - Human molecular genetics, 2014 - academic.oup.com
Observational epidemiological studies are prone to confounding, reverse causation and
various biases and have generated findings that have proved to be unreliable indicators of …
various biases and have generated findings that have proved to be unreliable indicators of …
[HTML][HTML] Quantification of the pace of biological aging in humans through a blood test, the DunedinPoAm DNA methylation algorithm
Biological aging is the gradual, progressive decline in system integrity that occurs with
advancing chronological age, causing morbidity and disability. Measurements of the pace of …
advancing chronological age, causing morbidity and disability. Measurements of the pace of …
[HTML][HTML] The EWAS Catalog: a database of epigenome-wide association studies
Epigenome-wide association studies (EWAS) seek to quantify associations between
traits/exposures and DNA methylation measured at thousands or millions of CpG sites …
traits/exposures and DNA methylation measured at thousands or millions of CpG sites …
Disease variants alter transcription factor levels and methylation of their binding sites
Most disease-associated genetic variants are noncoding, making it challenging to design
experiments to understand their functional consequences,. Identification of expression …
experiments to understand their functional consequences,. Identification of expression …
Interindividual methylomic variation across blood, cortex, and cerebellum: implications for epigenetic studies of neurological and neuropsychiatric phenotypes
Given the tissue-specific nature of epigenetic processes, the assessment of disease-relevant
tissue is an important consideration for epigenome-wide association studies (EWAS). Little …
tissue is an important consideration for epigenome-wide association studies (EWAS). Little …
[HTML][HTML] DNA methylation signatures link prenatal famine exposure to growth and metabolism
Periconceptional diet may persistently influence DNA methylation levels with phenotypic
consequences. However, a comprehensive assessment of the characteristics of prenatal …
consequences. However, a comprehensive assessment of the characteristics of prenatal …
Integrative analysis of multi-omics data for discovery and functional studies of complex human diseases
YV Sun, YJ Hu - Advances in genetics, 2016 - Elsevier
Complex and dynamic networks of molecules are involved in human diseases. High-
throughput technologies enable omics studies interrogating thousands to millions of makers …
throughput technologies enable omics studies interrogating thousands to millions of makers …
Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease
Alzheimer's disease (AD) is a chronic neurodegenerative disorder that is characterized by
progressive neuropathology and cognitive decline. We performed a cross-tissue analysis of …
progressive neuropathology and cognitive decline. We performed a cross-tissue analysis of …
[HTML][HTML] An integrated genetic-epigenetic analysis of schizophrenia: evidence for co-localization of genetic associations and differential DNA methylation
Background Schizophrenia is a highly heritable, neuropsychiatric disorder characterized by
episodic psychosis and altered cognitive function. Despite success in identifying genetic …
episodic psychosis and altered cognitive function. Despite success in identifying genetic …