Therapeutic strategies for hepatitis B virus infection: towards a cure
GC Fanning, F Zoulim, J Hou, A Bertoletti - Nature reviews Drug …, 2019 - nature.com
Chronic hepatitis B virus (HBV) infection is a common cause of liver disease globally, with a
disproportionately high burden in South-East Asia. Vaccines and nucleoside or nucleotide …
disproportionately high burden in South-East Asia. Vaccines and nucleoside or nucleotide …
Adaptive immunity in HBV infection
A Bertoletti, C Ferrari - Journal of hepatology, 2016 - Elsevier
During hepatitis B virus (HBV) infection, the presence of HBV-specific antibody producing B
cells and functional HBV-specific T cells (with helper or cytotoxic effects) ultimately …
cells and functional HBV-specific T cells (with helper or cytotoxic effects) ultimately …
Corticosteroid treatment of patients with coronavirus disease 2019 (COVID‐19)
Objectives To assess the efficacy of corticosteroid treatment of patients with coronavirus
disease 2019 (COVID‐19). Design, setting Observational study in the two COVID‐19 …
disease 2019 (COVID‐19). Design, setting Observational study in the two COVID‐19 …
HBV DNA integration and clonal hepatocyte expansion in chronic hepatitis B patients considered immune tolerant
WS Mason, US Gill, S Litwin, Y Zhou, S Peri, O Pop… - Gastroenterology, 2016 - Elsevier
Background & Aims Chronic infection with hepatitis B virus (HBV) progresses through
different phases. The first, called the immune-tolerant phase, has been associated with a …
different phases. The first, called the immune-tolerant phase, has been associated with a …
Hepatitis B virus persistence and reactivation
Y Shi, M Zheng - bmj, 2020 - bmj.com
Hepatitis B virus (HBV) infection causes chronic hepatitis and has long term complications.
Individuals ever infected with HBV are at risk of viral reactivation under certain …
Individuals ever infected with HBV are at risk of viral reactivation under certain …
[HTML][HTML] HBV-induced immune imbalance in the development of HCC
Y Chen, Z Tian - Frontiers in immunology, 2019 - frontiersin.org
Chronic hepatitis B virus (HBV) infection is one of the high-risk factors for human HCC.
Despite the integration of virus DNA and the oncoprotein HBx, chronic necroinflammation …
Despite the integration of virus DNA and the oncoprotein HBx, chronic necroinflammation …
Effects of hepatitis B surface antigen on virus-specific and global T cells in patients with chronic hepatitis B virus infection
Background & Aims Chronic hepatitis B virus (HBV) infection is characterized by the
presence of defective viral envelope proteins (hepatitis B surface antigen [HBsAg]) and the …
presence of defective viral envelope proteins (hepatitis B surface antigen [HBsAg]) and the …
[HTML][HTML] Immune responses and immunopathology in acute and chronic viral hepatitis
Hepatitis A virus (HAV), hepatitis B virus (HBV) and hepatitis C virus (HCV) are responsible
for most cases of viral hepatitis. Infection by each type of virus results in a different typical …
for most cases of viral hepatitis. Infection by each type of virus results in a different typical …
[HTML][HTML] Liver-mediated adaptive immune tolerance
M Zheng, Z Tian - Frontiers in immunology, 2019 - frontiersin.org
The liver is an immunologically tolerant organ that is uniquely equipped to limit
hypersensitivity to food-derived antigens and bacterial products through the portal vein and …
hypersensitivity to food-derived antigens and bacterial products through the portal vein and …
[HTML][HTML] Checkpoint inhibition through small molecule-induced internalization of programmed death-ligand 1
JJ Park, EP Thi, VH Carpio, Y Bi, AG Cole… - Nature …, 2021 - nature.com
Programmed death-ligand 1 is a glycoprotein expressed on antigen presenting cells,
hepatocytes, and tumors which upon interaction with programmed death-1, results in …
hepatocytes, and tumors which upon interaction with programmed death-1, results in …