Simple Summary Histone deacetylases (HDACs) are epigenetic regulators that influence
chromatin structure and gene transcription, but also the function of non-histone targets like …

Endometriosis is a chronic disorder of the female reproductive system which afflicts a great
number of women worldwide. Histone deacetylases (HDACs) prevent the relaxation of …

The development of drugs for the treatment of advanced prostate cancer (PCA) remains a
challenging task. In this study we have designed, synthesized and tested twenty-nine novel …

Introduction: Long non-coding RNA H19 (lncH19) is highly expressed in colorectal cancer
(CRC) and plays critical roles in tumor development, proliferation, metastasis, and drug …

Hepatocellular carcinoma (HCC) is a malignancy with high morbidity and mortality but lacks
effective treatments thus far. Although the emergence of immune checkpoint inhibitors in …

Histone deacetylase (HDAC) serves as a critical molecular regulator in the pathobiology of
various malignancies and have garnered attention as a viable target for therapeutic …

Simple Summary Although in the last decades the clinical outcome of cancer patients
considerably improved, the major drawbacks still associated with chemotherapy are the …

Sodium butyrate (NaBu) is a class I histone deacetylase inhibitor (HDACi) that can impede
the proliferation of transformed cells. Although some HDACi downregulate the expression of …

Breast cancer (BC) is a heterogeneous condition and comprises molecularly distinct
subtypes. An imbalance in the levels of epigenetic histone deacetylases (HDACs) …

Resistance to immune checkpoint blockade (ICB) therapy represents a formidable clinical
challenge limiting the efficacy of immunotherapy. In particular, prostate cancer poses a …