Green chemistry in the synthesis of pharmaceuticals

S Kar, H Sanderson, K Roy, E Benfenati… - Chemical …, 2021 - ACS Publications
The principles of green chemistry (GC) can be comprehensively implemented in green
synthesis of pharmaceuticals by choosing no solvents or green solvents (preferably water) …

Continuous Flow Upgrading of Selected C2–C6 Platform Chemicals Derived from Biomass

R Gerardy, DP Debecker, J Estager, P Luis… - Chemical …, 2020 - ACS Publications
The ever increasing industrial production of commodity and specialty chemicals inexorably
depletes the finite primary fossil resources available on Earth. The forecast of population …

[HTML][HTML] Scale-up of micro-and milli-reactors: An overview of strategies, design principles and applications

Z Dong, Z Wen, F Zhao, S Kuhn, T Noël - Chemical Engineering Science: X, 2021 - Elsevier
Continuous-flow microreactor technology has been embraced by researchers in academia
and industry due to its excellent transport properties and the increased safety and control …

[HTML][HTML] Scale-up of photochemical reactions: transitioning from lab scale to industrial production

SDA Zondag, D Mazzarella… - Annual Review of …, 2023 - annualreviews.org
In the past two decades, we have witnessed a rapid emergence of new and powerful
photochemical and photocatalytic synthetic methods. Although these methods have been …

Circular bioeconomy and integrated biorefinery in the production of xylooligosaccharides from lignocellulosic biomass: a review

CD Pinales-Márquez, RM Rodríguez-Jasso… - Industrial Crops and …, 2021 - Elsevier
Biorefineries are an operational processing strategy similar to classic petroleum
biorefineries in the production of energy and products. However, the biorefineries use …

A review on wound dressings: Antimicrobial agents, biomaterials, fabrication techniques, and stimuli-responsive drug release

E Naseri, A Ahmadi - European Polymer Journal, 2022 - Elsevier
Skin, the largest organ of the body, protects the inner organs against the ambient
environment, and it is prone to internal and external injuries in the form of wounds. The …

[HTML][HTML] Continuous flow asymmetric synthesis of chiral active pharmaceutical ingredients and their advanced intermediates

SB Ötvös, CO Kappe - Green Chemistry, 2021 - pubs.rsc.org
Catalytic enantioselective transformations provide well-established and direct access to
stereogenic synthons that are broadly distributed among active pharmaceutical ingredients …

Green chemistry and sustainability metrics in the pharmaceutical manufacturing sector

J Becker, C Manske, S Randl - Current Opinion in Green and Sustainable …, 2022 - Elsevier
This review article summarizes recent developments of green chemistry and sustainability
metrics with a focus on the pharmaceutical industry. We discuss synergies and …

Towards the standardization of flow chemistry protocols for organic reactions

CA Hone, CO Kappe - Chemistry‐Methods, 2021 - Wiley Online Library
Flow chemistry studies can sometimes be difficult to reproduce. In this article we provide
guidance to scientists for experimental details that should be considered as part of any …

Bayesian Self‐Optimization for Telescoped Continuous Flow Synthesis

AD Clayton, EO Pyzer‐Knapp, M Purdie… - Angewandte …, 2023 - Wiley Online Library
The optimization of multistep chemical syntheses is critical for the rapid development of new
pharmaceuticals. However, concatenating individually optimized reactions can lead to …