Antiphospholipid syndrome

K Schreiber, S Sciascia, PG De Groot… - Nature reviews Disease …, 2018 - nature.com
Antiphospholipid syndrome (APS) is an autoimmune disease characterized by the presence
of antiphospholipid antibodies, such as lupus anticoagulant, anticardiolipin antibodies and …

Aspirin: the mechanism of action revisited in the context of pregnancy complications

AP Cadavid - Frontiers in immunology, 2017 - frontiersin.org
Aspirin is one of the most frequently used and cheapest drugs in medicine. It belongs to the
non-steroidal anti-inflammatory drugs with a wide range of pharmacological activities …

Pathogenic autoreactive T and B cells cross-react with mimotopes expressed by a common human gut commensal to trigger autoimmunity

WE Ruff, C Dehner, WJ Kim, O Pagovich, CL Aguiar… - Cell host & …, 2019 - cell.com
Given the immense antigenic load present in the microbiome, we hypothesized that
microbiota mimotopes can be a persistent trigger in human autoimmunity via cross-reactivity …

Aspirin for prevention of preeclampsia and fetal growth restriction

L Loussert, F Vidal, O Parant, SM Hamdi… - Prenatal …, 2020 - Wiley Online Library
For the past decades, growing attention has been given to aspirin use during pregnancy. It
favors placentation by its proangiogenic, antithrombotic, and anti‐inflammatory effects …

Does low-dose aspirin initiated before 11 weeks' gestation reduce the rate of preeclampsia?

P Chaemsaithong, D Cuenca-Gomez, MN Plana… - American Journal of …, 2020 - Elsevier
Objective Data Preconception or early administration of low-dose aspirin might improve
endometrial growth, placental vascularization, and organogenesis. Most studies have …

[HTML][HTML] Antiphospholipid syndrome and pregnancy: pathogenesis to translation

VM Abrahams, LW Chamley… - Arthritis & rheumatology …, 2017 - ncbi.nlm.nih.gov
The antiphospholipid syndrome (APS) is an autoimmune condition associated with
thrombosis (venous or arterial) and adverse pregnancy outcomes. Investigation of APS …

Mechanisms of endothelial dysfunction in antiphospholipid syndrome: association with clinical manifestations

M Velásquez, M Rojas, VM Abrahams… - Frontiers in …, 2018 - frontiersin.org
The endothelium is a monolayer of cells that covers the inner surface of blood vessels and
its integrity is essential for the maintenance of vascular health. Endothelial dysfunction is a …

The treatment of anti-phospholipid syndrome: a comprehensive clinical approach

CB Chighizola, L Andreoli, M Gerosa, A Tincani… - Journal of …, 2018 - Elsevier
Anti-phospholipid syndrome (APS) is an acquired pro-thrombotic autoimmune disease that
predisposes to thrombotic events and/or obstetric complications, in the persistent presence …

The great obstetrical syndromes and the placenta

MK Hoffman - BJOG: An International Journal of Obstetrics & …, 2023 - Wiley Online Library
Although historically pre‐eclampsia, preterm birth, abruption, fetal growth restriction and
stillbirth have been viewed as clinically distinct entities, a growing body of literature has …

Antiphospholipid antibody‐activated NETs exacerbate trophoblast and endothelial cell injury in obstetric antiphospholipid syndrome

Y Lu, Y Dong, Y Zhang, D Shen, X Wang… - Journal of cellular …, 2020 - Wiley Online Library
Despite the widespread use of antiplatelets and anticoagulants, women with
antiphospholipid syndrome (APS) may face pregnancy complications associated with …