Kv7 channels are voltage-gated potassium channels encoded by KCNQ genes that have a
considerable physiological impact in many cell types. This reliance upon Kv7 channels for …

Alcohol Withdrawal Syndrome (AWS) is characterized as the termination of chronic and
sustained alcohol use that leads to severe symptoms of distress or loss of daily functions …

Alcohol use disorders (AUDs) and anxiety disorders (ADs) are often seen concurrently, but
their underlying cellular basis is unclear. For unclear reasons, the lateral habenula (LHb), a …

Major depressive disorder (MDD) is a leading cause of disability worldwide and less than
one-third of patients with MDD achieve stable remission of symptoms, despite currently …

Abstract Kv7. 1-Kv7. 5 (KCNQ1–5) K+ channels are voltage-gated K+ channels with major
roles in neurons, muscle cells and epithelia where they underlie physiologically important …

Substance use disorders (SUDs) are ubiquitous throughout the world. However, much
remains to be done to develop pharmacotherapies that are very efficacious because the …

K v 7 (“M-type,” KCNQ) K+ currents, play dominant roles in controlling neuronal excitability.
They act as a “brake” against hyperexcitable states in the central and peripheral nervous …

Cognitive impairments, uncontrolled drinking, and neuropathological cortical changes
characterize alcohol use disorder. Dysfunction of the orbitofrontal cortex (OFC), a critical …

KCNQ2 and KCNQ3 pathogenic channel variants have been associated with a spectrum of
developmentally regulated diseases that vary in age of onset, severity, and whether it is …

The prefrontal cortex (PFC) regulates drinking behaviors and affective changes following
chronic alcohol use. PFC activity is dynamically modulated by local inhibitory interneurons …