Intergenerational transmission of trauma effects: putative role of epigenetic mechanisms
This paper reviews the research evidence concerning the intergenerational transmission of
trauma effects and the possible role of epigenetic mechanisms in this transmission. Two …
trauma effects and the possible role of epigenetic mechanisms in this transmission. Two …
Neurobiological and systemic effects of chronic stress
BS McEwen - Chronic stress, 2017 - journals.sagepub.com
The brain is the central organ of stress and adaptation to stress because it perceives and
determines what is threatening, as well as the behavioral and physiological responses to the …
determines what is threatening, as well as the behavioral and physiological responses to the …
British Society of Gastroenterology guidelines on the management of irritable bowel syndrome
DH Vasant, PA Paine, CJ Black, LA Houghton… - Gut, 2021 - gut.bmj.com
Irritable bowel syndrome (IBS) remains one of the most common gastrointestinal disorders
seen by clinicians in both primary and secondary care. Since publication of the last British …
seen by clinicians in both primary and secondary care. Since publication of the last British …
Drivers of human development: How relationships and context shape learning and development 1
This article synthesizes knowledge on the role of relationships and key macro and micro-
contexts—poverty, racism, families, communities, schools, and peers—in supporting and/or …
contexts—poverty, racism, families, communities, schools, and peers—in supporting and/or …
Mechanisms of stress in the brain
The brain is the central organ involved in perceiving and adapting to social and physical
stressors via multiple interacting mediators, from the cell surface to the cytoskeleton to …
stressors via multiple interacting mediators, from the cell surface to the cytoskeleton to …
Stress effects on neuronal structure: hippocampus, amygdala, and prefrontal cortex
BS McEwen, C Nasca, JD Gray - Neuropsychopharmacology, 2016 - nature.com
The hippocampus provided the gateway into much of what we have learned about stress
and brain structural and functional plasticity, and this initial focus has expanded to other …
and brain structural and functional plasticity, and this initial focus has expanded to other …
Annual research review: Early adversity, the hypothalamic–pituitary–adrenocortical axis, and child psychopathology
Background Research on early adversity, stress biology, and child development has grown
exponentially in recent years. Findings We review the current evidence for the hypothalamic …
exponentially in recent years. Findings We review the current evidence for the hypothalamic …
[HTML][HTML] Neurobiology and consequences of social isolation stress in animal model—A comprehensive review
The brain is a vital organ, susceptible to alterations under genetic influences and
environmental experiences. Social isolation (SI) acts as a stressor which results in …
environmental experiences. Social isolation (SI) acts as a stressor which results in …
[HTML][HTML] Discriminative and affective touch: sensing and feeling
The multimodal properties of the human somatosensory system continue to be unravelled.
There is mounting evidence that one of these submodalities—touch—has another …
There is mounting evidence that one of these submodalities—touch—has another …
The neuroendocrinology of social isolation
Social isolation has been recognized as a major risk factor for morbidity and mortality in
humans for more than a quarter of a century. Although the focus of research has been on …
humans for more than a quarter of a century. Although the focus of research has been on …