The immune system and cancer have a complex relationship with the immune system
playing a dual role in tumor development. The effector cells of the immune system can …

B cells and the antibodies they produce have a deeply penetrating influence on human
physiology. Here, we review current understanding of how B cell responses are initiated; the …

Multi‐omics studies promise the improved characterization of biological processes across
molecular layers. However, methods for the unsupervised integration of the resulting …

Defects in apoptosis can promote tumorigenesis and impair responses of malignant B cells
to chemotherapeutics. Members of the B-cell leukemia/lymphoma-2 (BCL-2) family of …

Chronic lymphocytic leukaemia (CLL), the most frequent type of leukaemia in adults, is a
lymphoproliferative disorder that is characterized by the expansion of monoclonal, mature …

It has been nearly half a century since angioimmunoblastic T-cell lymphoma (AITL) was
characterized in the early 1970's. Our understanding of the disease has dramatically …

Abstract NOTCH1, NOTCH2, NOTCH3 and NOTCH4 are transmembrane receptors that
transduce juxtacrine signals of the delta‑like canonical Notch ligand (DLL) 1, DLL3, DLL4 …

Recent evidence suggests that complex karyotype (CK) defined by the presence of≥ 3
chromosomal aberrations (structural and/or numerical) identified by using chromosome …

Chronic lymphocytic leukemia (CLL) is a frequent hematological neoplasm in which
underlying epigenetic alterations are only partially understood. Here, we analyze the …

Abstract Treatment of chronic lymphocytic leukemia (CLL) has shifted from chemo-
immunotherapy to targeted agents. To define the evolutionary dynamics induced by targeted …