Bioactive peptides: From basic research to clinical trials and commercialization

P Duffuler, KS Bhullar… - Journal of agricultural …, 2022 - ACS Publications
Chronic diseases, including metabolic diseases, have become a worldwide public health
issue. Research regarding the use of bioactive peptides or protein hydrolysates derived from …

Nanotechnology-based drug delivery systems for Alzheimer's disease management: Technical, industrial, and clinical challenges

MM Wen, NS El-Salamouni, WM El-Refaie… - Journal of controlled …, 2017 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disease with high prevalence in the
rapidly growing elderly population in the developing world. The currently FDA approved …

Current trends and perspectives of bioactive peptides

EBM Daliri, BH Lee, DH Oh - Critical reviews in food science and …, 2018 - Taylor & Francis
The remarkable growth of therapeutic peptide development in the past decade has led to a
large number of market approvals and the market value is expected to hit $25 billion by …

[HTML][HTML] Central and peripheral control of food intake

MMI Abdalla - Endocrine regulations, 2017 - sciendo.com
The maintenance of the body weight at a stable level is a major determinant in keeping the
higher animals and mammals survive. The body weight depends on the balance between …

Galanin peptide family regulation of glucose metabolism

P Fang, M Yu, M Shi, P Bo, Z Zhang - Frontiers in Neuroendocrinology, 2020 - Elsevier
Recent preclinical and clinical studies have indicated that the galanin peptide family may
regulate glucose metabolism and alleviate insulin resistance, which diminishes the …

[HTML][HTML] Spexin-based galanin receptor type 2 agonist for comorbid mood disorders and abnormal body weight

S Yun, A Reyes-Alcaraz, YN Lee, HJ Yong… - Frontiers in …, 2019 - frontiersin.org
Despite the established comorbidity between mood disorders and abnormal eating
behaviors, the underlying molecular mechanism and therapeutics remain to be resolved …

[HTML][HTML] Neuropeptidergic control of feeding: Focus on the galanin family of peptides

P Marcos, R Coveñas - International Journal of Molecular Sciences, 2021 - mdpi.com
Obesity/overweight are important health problems due to metabolic complications.
Dysregulation of peptides exerting orexigenic/anorexigenic effects must be investigated in …

[HTML][HTML] Intranasal delivery of a methyllanthionine-stabilized galanin receptor-2-selective agonist reduces acute food intake

A Kuipers, M Balaskó, E Pétervári, A Koller… - …, 2021 - Elsevier
The regulatory (neuro) peptide galanin is widely distributed in the central and peripheral
nervous systems, where it mediates its effects via three G protein-coupled receptors (GAL 1 …

[HTML][HTML] Intranasal delivery of a Fas-blocking peptide attenuates Fas-mediated apoptosis in brain ischemia

I Ullah, K Chung, J Oh, J Beloor, S Bae, SC Lee… - Scientific reports, 2018 - nature.com
Ischemic stroke-induced neuronal cell death results in the permanent disabling of brain
function. Apoptotic mechanisms are thought to play a prominent role in neuronal injury and …

Pharmacomodulation of brain neuromedin U signaling as a potential therapeutic strategy

A Pałasz, JJ Worthington, Ł Filipczyk… - Journal of …, 2023 - Wiley Online Library
Neuromedin U (NMU) belongs to a family of multifunctional neuropeptides that modulate the
activity of several neural networks of the brain. Acting via metabotropic receptor NMUR2 …