Abstract Since the mid-1950's, melanoma incidence has been rising steadily in
industrialized Caucasian populations, thereby pointing to the pivotal involvement of …

Cancer immunotherapy aimed at boosting cancer-specific immunoresponses to eradicate
tumor cells has evolved as a new treatment modality. Nanoparticles incorporating antigens …

EF24 is a curcumin analog that has improved anticancer activity over curcumin, but its
therapeutic potential and mechanism of action is unknown, which is important to address as …

The microRNA miR-21 is overexpressed in many human cancers, wherein accumulating
evidence indicates that it functions as an oncogene. Here, we report that the cytokine IFN …

Glioblastoma (GBM) is an aggressive brain cancer with a poor prognosis. While surgical
resection is the primary treatment, adjuvant temozolomide (TMZ) chemotherapy and …

Traditional transfection agents including cationic lipids and polymers have high efficiency
but cause cytotoxicity. While cell penetrating peptide based transfection agents exhibit …

Background Induction of immunogenic cell death (ICD) is considered a promising strategy
for cancer immunotherapy. Stattic is an inhibitor of STAT3, which is found constitutively …

Abstract Glioma-Initiating Cells (GICs) are thought to be responsible for tumor initiation,
progression and recurrence in glioblastoma (GBM). In previous studies, we reported the …

To sustain their proliferation, cancer cells overcome negative-acting signals that restrain
their growth and promote senescence and cell death. Renalase (RNLS) is a secreted …

Cancer has a significant impact on public health around the world. Treating cancer by
chemotherapy or radiotherapy has several side effects. In combinational cancer therapy …