Genetics of chronic obstructive pulmonary disease: understanding the pathobiology and heterogeneity of a complex disorder
MH Cho, BD Hobbs, EK Silverman - The Lancet Respiratory …, 2022 - thelancet.com
Chronic obstructive pulmonary disease (COPD) is a deadly and highly morbid disease.
Susceptibility to and heterogeneity of COPD are incompletely explained by environmental …
Susceptibility to and heterogeneity of COPD are incompletely explained by environmental …
New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries
Reduced lung function predicts mortality and is key to the diagnosis of chronic obstructive
pulmonary disease (COPD). In a genome-wide association study in 400,102 individuals of …
pulmonary disease (COPD). In a genome-wide association study in 400,102 individuals of …
Genotype× environment interactions in gene regulation and complex traits
C Boye, S Nirmalan, A Ranjbaran, F Luca - Nature Genetics, 2024 - nature.com
Genotype× environment interactions (GxE) have long been recognized as a key mechanism
underlying human phenotypic variation. Technological developments over the past 15 years …
underlying human phenotypic variation. Technological developments over the past 15 years …
[HTML][HTML] Genome-wide by environment interaction studies of depressive symptoms and psychosocial stress in UK Biobank and Generation Scotland
A Arnau-Soler, E Macdonald-Dunlop, MJ Adams… - Translational …, 2019 - nature.com
Stress is associated with poorer physical and mental health. To improve our understanding
of this link, we performed genome-wide association studies (GWAS) of depressive …
of this link, we performed genome-wide association studies (GWAS) of depressive …
Emerging concepts and challenges in implementing the exposome paradigm in allergic diseases and asthma: a Practall document
Exposome research can improve the understanding of the mechanistic connections
between exposures and health to help mitigate adverse health outcomes across the life …
between exposures and health to help mitigate adverse health outcomes across the life …
A polygenic risk score for idiopathic pulmonary fibrosis and interstitial lung abnormalities
Rationale: In addition to rare genetic variants and the MUC5B locus, common genetic
variants contribute to idiopathic pulmonary fibrosis (IPF) risk. The predictive power of …
variants contribute to idiopathic pulmonary fibrosis (IPF) risk. The predictive power of …
The one health approach for allergic diseases and asthma
M Jutel, GS Mosnaim, JA Bernstein, S Del Giacco… - Allergy, 2023 - Wiley Online Library
Abstract The One Health approach is a collaborative and interdisciplinary strategy with focal
point on human, animal, and environmental health interconnections. One Health can …
point on human, animal, and environmental health interconnections. One Health can …
[HTML][HTML] Gene-lifestyle interactions in the genomics of human complex traits
V Laville, T Majarian, YJ Sung, K Schwander… - European Journal of …, 2022 - nature.com
The role and biological significance of gene-environment interactions in human traits and
diseases remain poorly understood. To address these questions, the CHARGE Gene …
diseases remain poorly understood. To address these questions, the CHARGE Gene …
[HTML][HTML] Whole genome sequence analysis of pulmonary function and COPD in 19,996 multi-ethnic participants
Chronic obstructive pulmonary disease (COPD), diagnosed by reduced lung function, is a
leading cause of morbidity and mortality. We performed whole genome sequence (WGS) …
leading cause of morbidity and mortality. We performed whole genome sequence (WGS) …
Interaction of cigarette smoking and polygenic risk score on reduced lung function
Importance The risk of airflow limitation and chronic obstructive pulmonary disease (COPD)
is influenced by combinations of cigarette smoking and genetic susceptibility, yet it remains …
is influenced by combinations of cigarette smoking and genetic susceptibility, yet it remains …