Green Synthesis of Aromatic Nitrogen-Containing Heterocycles by Catalytic and Non-Traditional Activation Methods

RB Vlocskó, G Xie, B Török - Molecules, 2023 - mdpi.com
Recent advances in the environmentally benign synthesis of aromatic N-heterocycles are
reviewed, focusing primarily on the application of catalytic methods and non-traditional …

Recent advances in the synthesis and utility of thiazoline and its derivatives

S Kumar, A Arora, S Sapra, R Kumar, BK Singh… - RSC …, 2024 - pubs.rsc.org
Thiazolines and their derivatives hold significant importance in the field of medicinal
chemistry due to their promising potential as pharmaceutical agents. These molecular …

New pyrazolopyridine and pyrazolothiazole-based compounds as anti-proliferative agents targeting c-Met kinase inhibition: design, synthesis, biological evaluation …

ZM Alamshany, EM Algamdi, IMM Othman, MM Anwar… - RSC …, 2023 - pubs.rsc.org
c-Met tyrosine kinase plays a key role in the oncogenic process. Inhibition of the c-Met has
emerged as an attractive target for human cancer treatment. This work deals with the design …

New 1, 2, 3-Triazole-Coumarin-Glycoside Hybrids and Their 1, 2, 4-triazolyl thioglycoside analogs targeting mitochondria apoptotic pathway: Synthesis, anticancer …

WA El-Sayed, FM Alminderej, MM Mounier, ES Nossier… - Molecules, 2022 - mdpi.com
Toxicity and resistance to newly synthesized anticancer drugs represent a challenging
phenomenon of intensified concern arising from variation in drug targets and consequently …

Novel pyridine-thiazolidinone-triazole hybrid glycosides targeting EGFR and CDK-2: Design, synthesis, anticancer evaluation, and molecular docking simulation

AF Kassem, MA Omar, ES Nossier, HM Awad… - Journal of Molecular …, 2023 - Elsevier
The observed toxicity of newly designed anticancer drugs is considered as an impediment
challenging phenomenon of intense concern arising from diversity in drug targets and the …

Cd (II) complexes derived from thiazoline, hydrazide and carbodithioate ligands: synthesis, crystal structures and electrochemical sensing of uric acid

S Jaiswal, SK Pandey, J Prajapati… - Applied …, 2023 - Wiley Online Library
Three novel Cd (II) metal complexes 1–3 have been synthesized with different derivatives of
thiazoline, hydrazide and carbodithioate. These metal complexes are abbreviated as [Cd …

New sulfonamide-based glycosides incorporated 1, 2, 3-triazole as cytotoxic agents through VEGFR-2 and carbonic anhydrase inhibitory activity

HAS Abbas, ES Nossier, MA El-Manawaty… - Scientific Reports, 2024 - nature.com
New sulfonamide-triazole-glycoside hybrids derivatives were designed, synthesised, and
investigated for anticancer efficacy. The target glycosides' cytotoxic activity was studied with …

A review on structure-function mechanism and signaling pathway of serine/threonine protein PIM kinases as a therapeutic target

AK Rout, B Dehury, SN Parida, SS Rout, R Jena… - International Journal of …, 2024 - Elsevier
The proviral integration for the Moloney murine leukemia virus (PIM) kinases, belonging to
serine/threonine kinase family, have been found to be overexpressed in various types of …

A decade's overview of 2‐aminothiophenes and their fused analogs as promising anticancer agents

DG Darwish, HAM El‐Sherief… - Archiv der …, 2024 - Wiley Online Library
Over the past decades, cancer has been a challenging domain for medicinal chemists as it
is an international health concern. In association, small molecules such as 2 …

Synthesis of a new series of 4-pyrazolylquinolinones with apoptotic antiproliferative effects as dual EGFR/BRAF V600E inhibitors

LH Al-Wahaibi, BGM Youssif, HA Abou-Zied… - RSC Medicinal …, 2024 - pubs.rsc.org
The current study focuses on developing a single molecule that acts as an antiproliferative
agent with dual or multi-targeted action, reducing drug resistance and adverse effects. A …