Green Synthesis of Aromatic Nitrogen-Containing Heterocycles by Catalytic and Non-Traditional Activation Methods
Recent advances in the environmentally benign synthesis of aromatic N-heterocycles are
reviewed, focusing primarily on the application of catalytic methods and non-traditional …
reviewed, focusing primarily on the application of catalytic methods and non-traditional …
Recent advances in the synthesis and utility of thiazoline and its derivatives
S Kumar, A Arora, S Sapra, R Kumar, BK Singh… - RSC …, 2024 - pubs.rsc.org
Thiazolines and their derivatives hold significant importance in the field of medicinal
chemistry due to their promising potential as pharmaceutical agents. These molecular …
chemistry due to their promising potential as pharmaceutical agents. These molecular …
New pyrazolopyridine and pyrazolothiazole-based compounds as anti-proliferative agents targeting c-Met kinase inhibition: design, synthesis, biological evaluation …
ZM Alamshany, EM Algamdi, IMM Othman, MM Anwar… - RSC …, 2023 - pubs.rsc.org
c-Met tyrosine kinase plays a key role in the oncogenic process. Inhibition of the c-Met has
emerged as an attractive target for human cancer treatment. This work deals with the design …
emerged as an attractive target for human cancer treatment. This work deals with the design …
New 1, 2, 3-Triazole-Coumarin-Glycoside Hybrids and Their 1, 2, 4-triazolyl thioglycoside analogs targeting mitochondria apoptotic pathway: Synthesis, anticancer …
Toxicity and resistance to newly synthesized anticancer drugs represent a challenging
phenomenon of intensified concern arising from variation in drug targets and consequently …
phenomenon of intensified concern arising from variation in drug targets and consequently …
Novel pyridine-thiazolidinone-triazole hybrid glycosides targeting EGFR and CDK-2: Design, synthesis, anticancer evaluation, and molecular docking simulation
AF Kassem, MA Omar, ES Nossier, HM Awad… - Journal of Molecular …, 2023 - Elsevier
The observed toxicity of newly designed anticancer drugs is considered as an impediment
challenging phenomenon of intense concern arising from diversity in drug targets and the …
challenging phenomenon of intense concern arising from diversity in drug targets and the …
Cd (II) complexes derived from thiazoline, hydrazide and carbodithioate ligands: synthesis, crystal structures and electrochemical sensing of uric acid
Three novel Cd (II) metal complexes 1–3 have been synthesized with different derivatives of
thiazoline, hydrazide and carbodithioate. These metal complexes are abbreviated as [Cd …
thiazoline, hydrazide and carbodithioate. These metal complexes are abbreviated as [Cd …
New sulfonamide-based glycosides incorporated 1, 2, 3-triazole as cytotoxic agents through VEGFR-2 and carbonic anhydrase inhibitory activity
HAS Abbas, ES Nossier, MA El-Manawaty… - Scientific Reports, 2024 - nature.com
New sulfonamide-triazole-glycoside hybrids derivatives were designed, synthesised, and
investigated for anticancer efficacy. The target glycosides' cytotoxic activity was studied with …
investigated for anticancer efficacy. The target glycosides' cytotoxic activity was studied with …
A review on structure-function mechanism and signaling pathway of serine/threonine protein PIM kinases as a therapeutic target
The proviral integration for the Moloney murine leukemia virus (PIM) kinases, belonging to
serine/threonine kinase family, have been found to be overexpressed in various types of …
serine/threonine kinase family, have been found to be overexpressed in various types of …
A decade's overview of 2‐aminothiophenes and their fused analogs as promising anticancer agents
DG Darwish, HAM El‐Sherief… - Archiv der …, 2024 - Wiley Online Library
Over the past decades, cancer has been a challenging domain for medicinal chemists as it
is an international health concern. In association, small molecules such as 2 …
is an international health concern. In association, small molecules such as 2 …
Synthesis of a new series of 4-pyrazolylquinolinones with apoptotic antiproliferative effects as dual EGFR/BRAF V600E inhibitors
The current study focuses on developing a single molecule that acts as an antiproliferative
agent with dual or multi-targeted action, reducing drug resistance and adverse effects. A …
agent with dual or multi-targeted action, reducing drug resistance and adverse effects. A …