Mechanisms of metastasis in colorectal cancer and metastatic organotropism: hematogenous versus peritoneal spread

E Pretzsch, F Bösch, J Neumann… - Journal of …, 2019 - Wiley Online Library
Metastasis is the major cause of death in patients with colorectal carcinoma (CRC). The
most common sites of metastasis are the liver and the peritoneum. Peritoneal …

[HTML][HTML] Regulation of Src family kinases during colorectal cancer development and its clinical implications

W Jin - Cancers, 2020 - mdpi.com
Src family kinases (SFKs) are non-receptor kinases that play a critical role in the
pathogenesis of colorectal cancer (CRC). The expression and activity of SFKs are …

[HTML][HTML] Caveolin-1-mediated sphingolipid oncometabolism underlies a metabolic vulnerability of prostate cancer

J Vykoukal, JF Fahrmann, JR Gregg, Z Tang… - Nature …, 2020 - nature.com
Plasma and tumor caveolin-1 (Cav-1) are linked with disease progression in prostate
cancer. Here we report that metabolomic profiling of longitudinal plasmas from a prospective …

NDRG1 in aggressive breast cancer progression and brain metastasis

ES Villodre, X Hu, BL Eckhardt, R Larson… - JNCI: Journal of the …, 2022 - academic.oup.com
Background N-Myc downstream regulated gene 1 (NDRG1) suppresses metastasis in many
human malignancies, including breast cancer, yet has been associated with worse survival …

Claudin‐2 promotes colorectal cancer growth and metastasis by suppressing NDRG1 transcription

M Wei, Y Zhang, X Yang, P Ma, Y Li… - Clinical and …, 2021 - Wiley Online Library
Colorectal cancer (CRC) is one of the most common malignant tumours, with multiple driving
factors and biological transitions involved in its development. Claudin‐2 (CLDN2), a well …

[HTML][HTML] Potassium channel activity controls breast cancer metastasis by affecting β-catenin signaling

EK Breuer, D Fukushiro-Lopes, A Dalheim… - Cell death & …, 2019 - nature.com
Potassium ion channels are critical in the regulation of cell motility. The acquisition of cell
motility is an essential parameter of cancer metastasis. However, the role of K+ channels in …

Cell adhesiveness serves as a biophysical marker for metastatic potential

P Beri, A Popravko, B Yeoman, A Kumar, K Chen… - Cancer research, 2020 - AACR
Tumors are heterogeneous and composed of cells with different dissemination abilities.
Despite significant effort, there is no universal biological marker that serves as a metric for …

A novel prognostic signature of immune‐related genes for patients with colorectal cancer

J Wang, S Yu, G Chen, M Kang, X Jin… - Journal of cellular …, 2020 - Wiley Online Library
Colorectal cancer (CRC) is one of the most commonly diagnosed cancers with an estimated
1.8 million new cases worldwide and associated with high mortality rates of 881 000 CRC …

[PDF][PDF] Deregulated expression of the imprinted DLK1-DIO3 region in glioblastoma stemlike cells: tumor suppressor role of lncRNA MEG3

M Buccarelli, V Lulli, A Giuliani, M Signore… - Neuro …, 2020 - academic.oup.com
Background Glioblastoma (GBM) stemlike cells (GSCs) are thought to be responsible for the
maintenance and aggressiveness of GBM, the most common primary brain tumor in adults …

Pharmacological targeting and the diverse functions of the metastasis suppressor, NDRG1, in cancer

KC Park, J Paluncic, Z Kovacevic… - Free Radical Biology and …, 2020 - Elsevier
N-myc downstream regulated gene-1 (NDRG1) is a potent metastasis suppressor that is
regulated by hypoxia, metal ions including iron, the free radical nitric oxide (NO.), and …