Objectives To comprehensively summarize and meta-analyze the concurrence across voxel-
based morphometric (VBM) neuroimaging studies of migraine. Methods Neuroimaging …

The neuroimmune mechanism underlying neuropathic pain has been extensively studied.
Tumor necrosis factor-alpha (TNF-α), a key pro-inflammatory cytokine that drives cytokine …

Central sensitization (CS) is defined as an increased nociceptive responsiveness due to
sensitization of neurons in the central nervous system, usually the result of prolonged …

Persistent fatigue is often reported in those with chronic musculoskeletal pain. Separately,
both chronic pain and chronic fatigue contribute to physical and cognitive decline in older …

Opioid receptor agonists, particularly those that activate µ-opioid receptors (MORs), are
essential analgesic agents for acute or chronic mild to severe pain treatment. However, their …

There are more than 200 opioid overdose deaths each day in the US. In combating this
epidemic we look to available treatment tools. Here, we find only three medications …

Objectives Cancer-related cognitive impairment (CRCI) is a common side effect of breast
cancer treatment and has been linked to structural brain abnormalities. As previous research …

Background: The successful regulation of sensory input to the central nervous system
depends on the descending pain modulatory system (DPMS). For the effective regulation of …

Cognitive dysfunction, pain, and psychological morbidity all present unique challenges to
those living with traumatic brain injury (TBI). In this study we examined (a) the impact of pain …

Objective To phenotype SLE based on symptom burden (disease damage, system
involvement and patient reported outcomes), with a specific focus on objective and …