The neurobiology of drug addiction: cross-species insights into the dysfunction and recovery of the prefrontal cortex

AO Ceceli, CW Bradberry, RZ Goldstein - Neuropsychopharmacology, 2022 - nature.com
A growing preclinical and clinical body of work on the effects of chronic drug use and drug
addiction has extended the scope of inquiry from the putative reward-related subcortical …

Epigenetic mechanisms of opioid addiction

CJ Browne, A Godino, M Salery, EJ Nestler - Biological psychiatry, 2020 - Elsevier
Opioid use kills tens of thousands of Americans each year, devastates families and entire
communities, and cripples the health care system. Exposure to opioids causes long-term …

[HTML][HTML] Transcriptional alterations in dorsolateral prefrontal cortex and nucleus accumbens implicate neuroinflammation and synaptic remodeling in opioid use …

ML Seney, SM Kim, JR Glausier, MA Hildebrand… - Biological …, 2021 - Elsevier
Background Prevalence rates of opioid use disorder (OUD) have increased dramatically,
accompanied by a surge of overdose deaths. While opioid dependence has been …

[HTML][HTML] Suicide risk and addiction: the impact of alcohol and opioid use disorders

MM Rizk, S Herzog, S Dugad, B Stanley - Current addiction reports, 2021 - Springer
Abstract Purpose of Review Suicide is a major public health concern and a leading cause of
death in the US. Alcohol and opioid use disorders (AUD/OUD) significantly increase risk for …

[PDF][PDF] Emotion regulation in substance use disorders

H Kober, D Bolling - Handbook of emotion regulation, 2014 - gruberpeplab.com
Have you ever had coffee or rea? A glass of winp? S-olrrd even) single: igare. re? Virrually.
rll. rclulr'reporr consumirg psychoacrive. d-trgsr at sc me, poinr in r\err lires, srg, gesnng rh …

[HTML][HTML] Abnormal white matter integrity in adolescents with internet addiction disorder: a tract-based spatial statistics study

F Lin, Y Zhou, Y Du, L Qin, Z Zhao, J Xu, H Lei - PloS one, 2012 - journals.plos.org
Background Internet addiction disorder (IAD) is currently becoming a serious mental health
issue around the globe. Previous studies regarding IAD were mainly focused on associated …

Nicotine addiction and nicotinic receptors: lessons from genetically modified mice

JP Changeux - Nature Reviews Neuroscience, 2010 - nature.com
The past decades have seen a revolution in our understanding of brain diseases and in
particular of drug addiction. This has been largely due to the identification of …

Addiction related alteration in resting-state brain connectivity

N Ma, Y Liu, N Li, CX Wang, H Zhang, XF Jiang, HS Xu… - Neuroimage, 2010 - Elsevier
It is widely accepted that addictive drug use is related to abnormal functional organization in
the user's brain. The present study aimed to identify this type of abnormality within the brain …

[HTML][HTML] Single-cell RNA-seq uncovers a robust transcriptional response to morphine by glia

D Avey, S Sankararaman, AKY Yim, R Barve… - Cell reports, 2018 - cell.com
Molecular and behavioral responses to opioids are thought to be primarily mediated by
neurons, although there is accumulating evidence that other cell types play a prominent role …

Factors underlying prefrontal and insula structural alterations in smokers

X Zhang, BJ Salmeron, TJ Ross, X Geng, Y Yang… - Neuroimage, 2011 - Elsevier
Based upon previous reports of alterations in white matter integrity and gray matter density
in smokers, we examined these markers in a large, well-matched sample of smokers and …