Antibiotic resistance is a major global health challenge and, worryingly, several key Gram
negative pathogens can become resistant to most currently available antibiotics. Polymyxins …

In recent years, the worldwide spread of the so-called high-risk clones of multidrug-resistant
or extensively drug-resistant (MDR/XDR) Pseudomonas aeruginosa has become a public …

Infections with Pseudomonas aeruginosa have become a real concern in hospital-acquired
infections, especially in critically ill and immunocompromised patients. The major problem …

Polymyxins are well-established antibiotics that have recently regained significant interest
as a consequence of the increasing incidence of infections due to multidrug-resistant Gram …

Pseudomonas aeruginosa is an opportunistic pathogen affecting immunocompromised
patients. It is known as the leading cause of morbidity and mortality in cystic fibrosis (CF) …

Polymyxins are polycationic antimicrobial peptides that are currently the last-resort
antibiotics for the treatment of multidrug-resistant, Gram-negative bacterial infections. The …

Following their initial discovery in the 1940s, polymyxin antibiotics fell into disfavor due to
their potential clinical toxicity, especially nephrotoxicity. However, the dry antibiotic …

The bacterial membrane provides a target for antimicrobial peptides. There are two groups
of bacteria that have characteristically different surface membranes. One is the Gram …

Multidrug resistance is quite common among non-fermenting Gram-negative rods, in
particular among clinically relevant species including Pseudomonas aeruginosa and …

The increasing prevalence of chronic and hospital-acquired infections produced by
multidrug-resistant (MDR) or extensively drug-resistant (XDR) Pseudomonas aeruginosa …