Regulation of cholesterol homeostasis in health and diseases: from mechanisms to targeted therapeutics
Y Duan, K Gong, S Xu, F Zhang, X Meng… - Signal Transduction and …, 2022 - nature.com
Disturbed cholesterol homeostasis plays critical roles in the development of multiple
diseases, such as cardiovascular diseases (CVD), neurodegenerative diseases and …
diseases, such as cardiovascular diseases (CVD), neurodegenerative diseases and …
The epidemiology of Parkinson's disease: risk factors and prevention
A Ascherio, MA Schwarzschild - The Lancet Neurology, 2016 - thelancet.com
Since 2006, several longitudinal studies have assessed environmental or behavioural
factors that seem to modify the risk of developing Parkinson's disease. Increased risk of …
factors that seem to modify the risk of developing Parkinson's disease. Increased risk of …
Side effects of statins: from pathophysiology and epidemiology to diagnostic and therapeutic implications
Abstract Treatment with statins, inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A
reductase, has proven beneficial preventive effects on cardiovascular events. However …
reductase, has proven beneficial preventive effects on cardiovascular events. However …
Alpha-synuclein structure and Parkinson's disease–lessons and emerging principles
RM Meade, DP Fairlie, JM Mason - Molecular neurodegeneration, 2019 - Springer
Alpha-synuclein (αS) is the major constituent of Lewy bodies and a pathogenic hallmark of
all synucleinopathathies, including Parkinson's disease (PD), dementia with Lewy bodies …
all synucleinopathathies, including Parkinson's disease (PD), dementia with Lewy bodies …
Cholesterol metabolism in neurodegenerative diseases: molecular mechanisms and therapeutic targets
L Dai, L Zou, L Meng, G Qiang, M Yan, Z Zhang - Molecular neurobiology, 2021 - Springer
Cholesterol is an indispensable component of the cell membrane and plays vital roles in
critical physiological processes. Brain cholesterol accounts for a large portion of total …
critical physiological processes. Brain cholesterol accounts for a large portion of total …
[HTML][HTML] Enhancing autophagy in Alzheimer's disease through drug repositioning
Alzheimer's disease (AD) is one of the biggest human health threats due to increases in
aging of the global population. Unfortunately, drugs for treating AD have been largely …
aging of the global population. Unfortunately, drugs for treating AD have been largely …
Prediction of drug-target interactions and drug repositioning via network-based inference
Drug-target interaction (DTI) is the basis of drug discovery and design. It is time consuming
and costly to determine DTI experimentally. Hence, it is necessary to develop computational …
and costly to determine DTI experimentally. Hence, it is necessary to develop computational …
Statin use and risk of dementia or Alzheimer's disease: a systematic review and meta-analysis of observational studies
E Olmastroni, G Molari, N De Beni… - European journal of …, 2022 - academic.oup.com
Aims As the potential impact of statins on cognitive decline and dementia is still debated, we
conducted a meta-analysis of observational studies to examine the effect of statin use on the …
conducted a meta-analysis of observational studies to examine the effect of statin use on the …
The role of lipids in Parkinson's disease
H Xicoy, B Wieringa, GJM Martens - Cells, 2019 - mdpi.com
Parkinson's disease (PD) is a neurodegenerative disease characterized by a progressive
loss of dopaminergic neurons from the nigrostriatal pathway, formation of Lewy bodies, and …
loss of dopaminergic neurons from the nigrostriatal pathway, formation of Lewy bodies, and …
Linking lipids to Alzheimer's disease: cholesterol and beyond
G Di Paolo, TW Kim - Nature Reviews Neuroscience, 2011 - nature.com
Lipid-mediated signalling regulates a plethora of physiological processes, including crucial
aspects of brain function. In addition, dysregulation of lipid pathways has been implicated in …
aspects of brain function. In addition, dysregulation of lipid pathways has been implicated in …