Simple Summary It was found that long-established tumor-derived cell lines do not
adequately reproduce drug sensitivity and behavior of a real human cancers. Therefore …

Simple Summary The chorioallantoic membrane (CAM) model is an alternative in vivo test
system for the study of hallmarks of cancer such as angiogenesis, tumor growth, immune …

Owing to their uniform and tunable particle size, pore size, and shape, along with their
modular surface chemistry and biocompatibility, mesoporous silica nanoparticles (MSNs) …

A variety of in vivo experimental models have been established for the studies of human
cancer using both cancer cell lines and patient-derived xenografts (PDXs). In order to meet …

Osteosarcoma is a malignant primary tumor of bone, arising from transformed progenitor
cells with osteoblastic differentiation and osteoid production. While categorized as a rare …

Glioblastoma (GBM) is a malignant brain tumor with few therapeutic options. The disease
presents with a complex spectrum of genomic aberrations, but the pharmacological …

We postulate that nanoparticles (NPs) for use in therapeutic applications have largely not
realized their clinical potential due to an overall inability to use in vitro results to predict NP …

Introduction: Advancements in cancer management and treatment are associated with
strong preclinical research data, in which reliable cancer models are demanded. Indeed …

In the last decade, the chicken chorioallantoic membrane (CAM) assay has been re-
discovered in cancer research to study the molecular mechanisms of anti-cancer drug …

Considering cancer not only as malignant cells on their own but as a complex disease in
which tumor cells interact and communicate with their microenvironment has motivated the …