The role of astrocytic glutamate transporters GLT-1 and GLAST in neurological disorders: Potential targets for neurotherapeutics
Glutamate is the primary excitatory neurotransmitter in the central nervous system (CNS)
which initiates rapid signal transmission in the synapse before its re-uptake into the …
which initiates rapid signal transmission in the synapse before its re-uptake into the …
[HTML][HTML] Functions of N6-methyladenosine and its role in cancer
L He, H Li, A Wu, Y Peng, G Shu, G Yin - Molecular cancer, 2019 - Springer
Abstract N6-methyladenosine (m6A) is methylation that occurs in the N6-position of
adenosine, which is the most prevalent internal modification on eukaryotic mRNA …
adenosine, which is the most prevalent internal modification on eukaryotic mRNA …
[HTML][HTML] NSUN2 modified by SUMO-2/3 promotes gastric cancer progression and regulates mRNA m5C methylation
Y Hu, C Chen, X Tong, S Chen, X Hu, B Pan… - Cell death & …, 2021 - nature.com
Abstract The 5-methylcytosine (m5C) RNA methyltransferase NSUN2 is involved in the
regulation of cell proliferation and metastasis formation and is upregulated in multiple …
regulation of cell proliferation and metastasis formation and is upregulated in multiple …
Obstacles and opportunities in the functional analysis of extracellular vesicle RNA–an ISEV position paper
The release of RNA-containing extracellular vesicles (EV) into the extracellular milieu has
been demonstrated in a multitude of different in vitro cell systems and in a variety of body …
been demonstrated in a multitude of different in vitro cell systems and in a variety of body …
Post-translational modification of RNA m6A demethylase ALKBH5 regulates ROS-induced DNA damage response
Faithful genome integrity maintenance plays an essential role in cell survival. Here, we
identify the RNA demethylase ALKBH5 as a key regulator that protects cells from DNA …
identify the RNA demethylase ALKBH5 as a key regulator that protects cells from DNA …
Strategies for optimization of heterologous protein expression in E. coli: Roadblocks and reinforcements
J Kaur, A Kumar, J Kaur - International journal of biological …, 2018 - Elsevier
E. coli is most preferred system used for the production of recombinant proteins in bacteria
and the availability of improved genetic tools/methods are making it more valuable than …
and the availability of improved genetic tools/methods are making it more valuable than …
Cyclic decidualization of the human endometrium in reproductive health and failure
B Gellersen, JJ Brosens - Endocrine reviews, 2014 - academic.oup.com
Decidualization denotes the transformation of endometrial stromal fibroblasts into
specialized secretory decidual cells that provide a nutritive and immunoprivileged matrix …
specialized secretory decidual cells that provide a nutritive and immunoprivileged matrix …
A comprehensive compilation of SUMO proteomics
IA Hendriks, ACO Vertegaal - Nature reviews Molecular cell biology, 2016 - nature.com
Small ubiquitin-like modifiers (SUMOs) are essential for the regulation of several cellular
processes and are potential therapeutic targets owing to their involvement in diseases such …
processes and are potential therapeutic targets owing to their involvement in diseases such …
Enhancer–promoter interactions are encoded by complex genomic signatures on looping chromatin
S Whalen, RM Truty, KS Pollard - Nature genetics, 2016 - nature.com
Discriminating the gene target of a distal regulatory element from other nearby transcribed
genes is a challenging problem with the potential to illuminate the causal underpinnings of …
genes is a challenging problem with the potential to illuminate the causal underpinnings of …
[HTML][HTML] Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs
C Villarroya-Beltri, C Gutiérrez-Vázquez… - Nature …, 2013 - nature.com
Exosomes are released by most cells to the extracellular environment and are involved in
cell-to-cell communication. Exosomes contain specific repertoires of mRNAs, microRNAs …
cell-to-cell communication. Exosomes contain specific repertoires of mRNAs, microRNAs …