Hepatitis B virus (HBV) is a non-cytopathic, hepatotropic virus with the potential to cause a
persistent infection, ultimately leading to cirrhosis and hepatocellular carcinoma. Over the …

The liver's unique characteristics have a profound impact on the priming and maintenance of
adaptive immunity. This review delves into the cellular circuits that regulate adaptive …

The need for an accurate, fast and reliable analysis of carbohydrate test is crucial for
numerous biological processes. In that sense, anthrone–sulfuric acid assay is one of the …

TLR ligands are promising candidates for the development of novel vaccine adjuvants that
can elicit protective immunity against emerging infectious diseases. Adjuvants have been …

Worldwide, hepatocellular carcinoma (HCC) is one of the most common cancers. It is
thought that 80% of hepatocellular carcinomas are linked to chronic infections with the …

Highlights•Prophylactic vaccines work well, but we still lack a successful therapeutic vaccine
able to break immune tolerance in chronic infection or cancer.•Chronic hepatitis B is …

Hepatitis B virus reactivation (HBVr) can occur in patients treated with immunosuppressive
medications. Risk stratification for HBVr based on hepatitis B virus (HBV) serology and viral …

Abstract Development of therapeutic vaccines/strategies to control chronic hepatitis B virus
(HBV) infection has been challenging because of HBV-induced tolerance. In this study, we …

Viral hepatitis B is an enigmatic disease in which the host's own immune response to
persistent viral infection may bring about host destruction through antiviral inflammatory …

A new detailed mathematical model for dynamics of immune response to hepatitis B is
proposed, which takes into account contributions from innate and adaptive immune …