Collagen remodeling along cancer progression providing a novel opportunity for cancer diagnosis and treatment

K Song, Z Yu, X Zu, G Li, Z Hu, Y Xue - International Journal of Molecular …, 2022 - mdpi.com
The extracellular matrix (ECM) is a significant factor in cancer progression. Collagens, as the
main component of the ECM, are greatly remodeled alongside cancer development. More …

Role of transforming growth factor-β in peripheral nerve regeneration

Z Ding, M Jiang, J Qian, D Gu, H Bai… - Neural Regeneration …, 2023 - journals.lww.com
Injuries caused by trauma and neurodegenerative diseases can damage the peripheral
nervous system and cause functional deficits. Unlike in the central nervous system …

Interplay of Developmental Hippo–Notch Signaling Pathways with the DNA Damage Response in Prostate Cancer

I Mourkioti, A Angelopoulou, K Belogiannis, N Lagopati… - Cells, 2022 - mdpi.com
Prostate cancer belongs in the class of hormone-dependent cancers, representing a major
cause of cancer incidence in men worldwide. Since upon disease onset almost all prostate …

[HTML][HTML] Advances in landscape and related therapeutic targets of the prostate tumor microenvironment: Therapeutic targets of the prostate tumor microenvironment

D Li, W Xu, Y Chang, Y Xiao, Y He… - Acta Biochimica et …, 2023 - ncbi.nlm.nih.gov
The distinct tumor microenvironment (TME) of prostate cancer (PCa), which promotes tumor
proliferation and progression, consists of various stromal cells, immune cells, and a dense …

Approaches for boosting antitumor immunity in prostate cancer therapy: A comprehensive review on drugs, products, and nanoparticles

D Chen, Y Hu - Journal of Drug Delivery Science and Technology, 2023 - Elsevier
Prostate cancers are among the common malignancies in men. Despite the availability of
various treatment options, including chemotherapy, radiotherapy, and surgery, the prognosis …

Extracellular Matrix-and Integrin Adhesion Complexes-Related Genes in the Prognosis of Prostate Cancer Patients' Progression-Free Survival

I Samaržija, P Konjevoda - Biomedicines, 2023 - mdpi.com
Prostate cancer is a heterogeneous disease, and one of the main obstacles in its
management is the inability to foresee its course. Therefore, novel biomarkers are needed …

Molecular heterogeneity in prostate cancer and the role of targeted therapy

S Khan, P Baligar, C Tandon, J Nayyar, S Tandon - Life Sciences, 2023 - Elsevier
Data collected from large-scale studies has shown that the incidence of prostate cancer
globally is on the rise, which could be attributed to an overall increase in lifespan. So, the …

Collagen-specific molecular magnetic resonance imaging of prostate cancer

A Kader, JO Kaufmann, DB Mangarova… - International journal of …, 2022 - mdpi.com
Constant interactions between tumor cells and the extracellular matrix (ECM) influence the
progression of prostate cancer (PCa). One of the key components of the ECM are collagen …

Using Machine Learning to Predict TP53 Mutation Status and Aggressiveness of Prostate Cancer from Routine Histology Images

F Bordeleau - Cancer Research, 2023 - AACR
Despite years of progress, we still lack reliable tools to predict the aggressiveness of tumors,
including in the case of prostate cancer. Biomarkers have been developed, but they often …

Identification of the hub genes associated with prostate cancer tumorigenesis

H Zhu, Q Lin, X Gao, X Huang - Frontiers in Oncology, 2023 - frontiersin.org
Introduction Prostate cancer (PCa) is one of the most common malignant tumors of the male
urogenital system; however, the underlying mechanisms remain largely unclear. This study …