[HTML][HTML] TRIM family contribute to tumorigenesis, cancer development, and drug resistance
N Huang, X Sun, P Li, X Liu, X Zhang, Q Chen… - … Hematology & Oncology, 2022 - Springer
The tripartite-motif (TRIM) family represents one of the largest classes of putative single
protein RING-finger E3 ubiquitin ligases. TRIM family is involved in a variety of cellular …
protein RING-finger E3 ubiquitin ligases. TRIM family is involved in a variety of cellular …
[HTML][HTML] The roles and targeting options of TRIM family proteins in tumor
Y Zhang, W Zhang, L Zheng, Q Guo - Frontiers in Pharmacology, 2022 - frontiersin.org
Tripartite motif (TRIM) containing proteins are a class of E3 ubiquitin ligases, which are
critically implicated in the occurrence and development of tumors. They can function through …
critically implicated in the occurrence and development of tumors. They can function through …
[HTML][HTML] TRIM35 ubiquitination regulates the expression of PKM2 tetramer and dimer and affects the malignant behaviour of breast cancer by regulating the Warburg …
H Wu, X Guo, Y Jiao, Z Wu, Q Lv - … Journal of Oncology, 2022 - spandidos-publications.com
Breast cancer has become the leading cause of death in females. After comprehensive
treatment, the lives of patients are still threatened by tumor metastasis and recurrence …
treatment, the lives of patients are still threatened by tumor metastasis and recurrence …
[HTML][HTML] Intricate confrontation: Research progress and application potential of TRIM family proteins in tumor immune escape
Background Tripartite motif (TRIM) family proteins have more than 80 members and are
widely found in various eukaryotic cells. Most TRIM family proteins participate in the …
widely found in various eukaryotic cells. Most TRIM family proteins participate in the …
[HTML][HTML] TRIM31: A molecule with a dual role in cancer
Y Guo, P Lin, Y Hua, C Wang - Frontiers in oncology, 2022 - frontiersin.org
Tripartite motif (TRIM) 31 is a new member of the TRIM family and functions as an E3
ubiquitin ligase. Abnormal TRIM31 expression leads to a variety of pathological conditions …
ubiquitin ligase. Abnormal TRIM31 expression leads to a variety of pathological conditions …
Neglected PTM in Animal Adipogenesis: E3-mediated Ubiquitination
H Ran, C Li, M Zhang, J Zhong, H Wang - Gene, 2023 - Elsevier
Ubiquitination is a widespread post-transcriptional modification (PTM) that occurs during
protein degradation in eukaryotes and participates in almost all physiological and …
protein degradation in eukaryotes and participates in almost all physiological and …
[PDF][PDF] E3 ligase Trim35 inhibits LSD1 demethylase activity through K63-linked ubiquitination and enhances anti-tumor immunity in NSCLC
F Tang, C Lu, X He, W Lin, B Xie, X Gao, Y Peng… - Cell Reports, 2023 - cell.com
Targeting lysine-specific histone demethylase 1A (LSD1) can improve tumor
immunogenicity of poorly immunogenic tumors, such as non-small cell lung cancer …
immunogenicity of poorly immunogenic tumors, such as non-small cell lung cancer …
[HTML][HTML] Multiomic analysis of microRNA-mediated regulation reveals a proliferative axis involving miR-10b in fibrolamellar carcinoma
Fibrolamellar carcinoma (FLC) is an aggressive liver cancer primarily afflicting adolescents
and young adults. Most patients with FLC harbor a heterozygous deletion on chromosome …
and young adults. Most patients with FLC harbor a heterozygous deletion on chromosome …
Regulation of lipid metabolism by E3 ubiquitin ligases in lipid-associated metabolic diseases
Y Zou, Y Zhang, M Li, K Cao, C Song, Z Zhang… - International Journal of …, 2024 - Elsevier
Previous studies have progressively elucidated the involvement of E3 ubiquitin (Ub) ligases
in regulating lipid metabolism. Ubiquitination, facilitated by E3 Ub ligases, modifies critical …
in regulating lipid metabolism. Ubiquitination, facilitated by E3 Ub ligases, modifies critical …
[HTML][HTML] Multipronged regulation of autophagy and apoptosis: emerging role of TRIM proteins
TRIM proteins are characterized by their conserved N-terminal RING, B-box, and coiled-coil
domains. These proteins are efficient regulators of autophagy, apoptosis, and innate …
domains. These proteins are efficient regulators of autophagy, apoptosis, and innate …