Arsenic: a review on a great health issue worldwide

G Genchi, G Lauria, A Catalano, A Carocci… - Applied Sciences, 2022 - mdpi.com
Arsenic intoxication represents a worldwide health problem and occurs mainly through
drinking water. Arsenic, a metalloid and naturally occurring element, is one of the most …

Natural dietary compounds in the treatment of arsenic toxicity

G Bjørklund, MS Rahaman, M Shanaida, R Lysiuk… - Molecules, 2022 - mdpi.com
Chronic exposure to arsenic (As) compounds leads to its accumulation in the body, with skin
lesions and cancer being the most typical outcomes. Treating As-induced diseases …

Salvianolic acid A attenuates arsenic-induced ferroptosis and kidney injury via HIF-2α/DUOX1/GPX4 and iron homeostasis

D Yang, X Xia, S Xi - Science of The Total Environment, 2024 - Elsevier
Arsenic (As) is a prevalent pollutant in the environment and causes a high frequency of
kidney disease in areas of high arsenic contamination, but its pathogenic mechanisms have …

Epigenetic dysregulations in arsenic-induced carcinogenesis

R Islam, L Zhao, Y Wang, G Lu-Yao, LZ Liu - Cancers, 2022 - mdpi.com
Simple Summary Arsenic is a chemical element that is toxic, and long-term exposure to it
causes cancers such as lung, skin, liver, and bladder cancers. Over 150 million people …

N6-methyladenosine plays a dual role in arsenic carcinogenesis by temporal-specific control of core target AKT1

T Zhao, D Sun, W Xiong, J Man, Q Zhang… - Journal of Hazardous …, 2023 - Elsevier
High-profile RNA epigenetic modification N 6-methyladenosine (m 6 A), as a double-edged
sword for cancer, can either promote or inhibit arsenic-induced skin carcinogenesis …

Temporal modulation of differential alternative splicing in HaCaT human keratinocyte cell line chronically exposed to arsenic for up to 28 wk

AP Ferragut Cardoso, M Banerjee… - Environmental …, 2022 - ehp.niehs.nih.gov
Background: Chronic arsenic exposure via drinking water is associated with an increased
risk of developing cancer and noncancer chronic diseases. Pre-mRNAs are often subject to …

[HTML][HTML] The role of ROS/p38 MAPK/NLRP3 inflammasome cascade in arsenic-induced depression-/anxiety-like behaviors of mice

X Liu, R Zhang, J Fan, Y Chen, H Wang, Y Ge… - Ecotoxicology and …, 2023 - Elsevier
Arsenic pollution in groundwater remains a serious public health concern around the world.
Recent years, arsenic-related neurological and psychiatric disorders have been reported …

Impact of individual factors on DNA methylation of drug metabolism genes: A systematic review

J Bian, J Zhao, Y Zhao, X Hao, S He… - Environmental and …, 2023 - Wiley Online Library
Individual differences in drug response have always existed in clinical treatment. Many non‐
genetic factors show non‐negligible impacts on personalized medicine. Emerging studies …

Integration of epigenetic mechanisms into non-genotoxic carcinogenicity hazard assessment: Focus on DNA methylation and histone modifications

D Desaulniers, P Vasseur, A Jacobs… - International Journal of …, 2021 - mdpi.com
Epigenetics involves a series of mechanisms that entail histone and DNA covalent
modifications and non-coding RNAs, and that collectively contribute to programing cell …

Associations of arsenic exposure and arsenic metabolism with the risk of non-alcoholic fatty liver disease

Y Liu, W Li, J Zhang, Y Yan, Q Zhou, Q Liu… - International Journal of …, 2024 - Elsevier
Growing evidences supported that arsenic exposure contributes to non-alcoholic fatty liver
disease (NAFLD) risk, but findings were still inconsistent. Additionally, once absorbed …