Transcription termination occurs when the polymerase is released after a transcription event,
thus delimitating transcription units; however, the functional importance of termination …

The pathway from gene activation in the nucleus to mRNA translation and decay at specific
locations in the cytoplasm is both streamlined and highly interconnected. This review …

Recent advances have fuelled rapid growth in our appreciation of the tremendous number,
diversity and biological importance of non-coding (nc) RNAs. Because ncRNAs typically …

The exosome complex of 3′→ 5′ exonucleases is an important component of the RNA-
processing machinery in eukaryotes. This complex functions in the accurate processing of …

Gene transcription in the cell nucleus is a complex and highly regulated process.
Transcription in eukaryotes requires three distinct RNA polymerases, each of which employs …

Eukaryotes and archaea use two sets of specialized ribonucleoproteins (RNPs) to carry out
sequence-specific methylation and pseudouridylation of RNA, the two most abundant types …

microRNA abundance has been shown to depend on the amount of the microprocessor
components or, in some cases, on specific auxiliary co‐factors. In this paper, we show that …

Termination of transcription by RNA polymerase II requires two distinct processes: The
formation of a defined 3′ end of the transcribed RNA, as well as the disengagement of RNA …

Hsp90 is a ubiquitous and essential molecular chaperone that plays central roles in many
signaling and other cellular pathways. The in vivo and in vitro activity of Hsp90 depends on …

Transcription termination at mRNA genes is linked to polyadenylation. Cleavage at the poly
(A) site generates an entry point for the Rat1/Xrn2 exonuclease, which degrades the …