Cancer is the second leading cause of death in US. Despite the emergence of new, targeted
agents, and the use of various therapeutic combinations, none of the available treatment …

With recent studies using genetic, epigenetic, and other molecular and neurochemical
approaches, a new era has begun in understanding pathophysiology of suicide. Emerging …

Methylation is one of the major epigenetic processes pivotal to our understanding of
carcinogenesis. It is now widely accepted that there is a relationship between DNA …

High grade serous ovarian cancer (HGSOC) is the most aggressive subtype of ovarian
cancer and HGSOC patients often appear with metastasis, leading to the poor prognosis. Up …

Cancer metastasis is a multistep process associated with the induction of an epithelial-
mesenchymal transition (EMT) and cancer stem cells (CSCs). Although significant progress …

Recurrence and metastasis remain the major obstacles to successful treatment of
hepatocellular carcinoma (HCC). Chromatin remodeling factor ARID2 is commonly mutated …

Plant cells grown in culture exhibit genetic and epigenetic instability. Using a combination of
chromatin immunoprecipitation and DNA methylation profiling on tiling microarrays, we have …

The combination of biology and nanotechnology has led to a new generation of
nanodevices that make it possible to characterize the chemical, mechanical, and other …

The epigenome, which comprises chromatin, associated proteins, and the pattern of
covalent modification of DNA by methylation, sets up and maintains gene expression …

MBD2 is the only member of a family of methyl-CpG-binding proteins that has been reported
to be both a transcriptional repressor and a DNA demethylase (dMTase). To understand the …