[HTML][HTML] Sex differences in cancer mechanisms

JB Rubin, JS Lagas, L Broestl, J Sponagel… - Biology of sex …, 2020 - Springer
We now know that cancer is many different diseases, with great variation even within a
single histological subtype. With the current emphasis on developing personalized …

Extracellular regulation of VEGF: isoforms, proteolysis, and vascular patterning

P Vempati, AS Popel, F Mac Gabhann - Cytokine & growth factor reviews, 2014 - Elsevier
The regulation of vascular endothelial growth factor A (VEGF) is critical to
neovascularization in numerous tissues under physiological and pathological conditions …

Therapeutic angiogenesis for critical limb ischaemia

BH Annex - Nature Reviews Cardiology, 2013 - nature.com
Peripheral arterial disease (PAD) is caused by occlusive atherosclerosis in a vascular bed
other than the heart. The lower extremity is the most-common location for PAD. Critical limb …

A systems biology view of blood vessel growth and remodelling

EA Logsdon, SD Finley, AS Popel… - Journal of cellular and …, 2014 - Wiley Online Library
Blood travels throughout the body in an extensive network of vessels–arteries, veins and
capillaries. This vascular network is not static, but instead dynamically remodels in response …

Retinal artery-vein classification via topology estimation

R Estrada, MJ Allingham, PS Mettu… - IEEE transactions on …, 2015 - ieeexplore.ieee.org
We propose a novel, graph-theoretic framework for distinguishing arteries from veins in a
fundus image. We make use of the underlying vessel topology to better classify small and …

3D-printed fluidic networks as vasculature for engineered tissue

IS Kinstlinger, JS Miller - Lab on a Chip, 2016 - pubs.rsc.org
Fabrication of vascular networks within engineered tissue remains one of the greatest
challenges facing the fields of biomaterials and tissue engineering. Historically, the …

[HTML][HTML] Understanding the principles of pattern formation driven by notch signaling by integrating experiments and theoretical models

F Bocci, JN Onuchic, MK Jolly - Frontiers in Physiology, 2020 - frontiersin.org
Notch signaling is an evolutionary conserved cell-cell communication pathway. Besides
regulating cell-fate decisions at an individual cell level, Notch signaling coordinates the …

A systems biology perspective on sVEGFR1: its biological function, pathogenic role and therapeutic use

FTH Wu, MO Stefanini, FM Gabhann… - Journal of cellular …, 2010 - Wiley Online Library
Introduction‐Angiogenesis in physiology and pathology‐Angiogenesis in current medicine‐
VEGF ligand and receptor system: where does sVEGFR1 fit?‐Ligands: the human VEGF …

A review of mathematical models for the formation of vascular networks

M Scianna, CG Bell, L Preziosi - Journal of theoretical biology, 2013 - Elsevier
Two major mechanisms are involved in the formation of blood vasculature: vasculogenesis
and angiogenesis. The former term describes the formation of a capillary-like network from …

[HTML][HTML] Cancer modeling: From mechanistic to data-driven approaches, and from fundamental insights to clinical applications

S Bekisz, L Geris - Journal of Computational Science, 2020 - Elsevier
Cancer is still one of the major causes of death worldwide. Even if its comprehension is
improving continuously, the complexity and heterogeneity of this group of diseases …