Vascular smooth muscle cell in atherosclerosis

DA Chistiakov, AN Orekhov, YV Bobryshev - Acta physiologica, 2015 - Wiley Online Library
Vascular smooth muscle cells (VSMC s) exhibit phenotypic and functional plasticity in order
to respond to vascular injury. In case of the vessel damage, VSMC s are able to switch from …

Vasa vasorum angiogenesis: key player in the initiation and progression of atherosclerosis and potential target for the treatment of cardiovascular disease

DG Sedding, EC Boyle, JAF Demandt… - Frontiers in …, 2018 - frontiersin.org
Plaque microvascularization and increased endothelial permeability are key players in the
development of atherosclerosis, from the initial stages of plaque formation to the occurrence …

Insulin resistance and cancer: in search for a causal link

E Chiefari, M Mirabelli, S La Vignera… - International journal of …, 2021 - mdpi.com
Insulin resistance (IR) is a condition which refers to individuals whose cells and tissues
become insensitive to the peptide hormone, insulin. Over the recent years, a wealth of data …

The regulatory role of micro RNA s in angiogenesis‐related diseases

LL Sun, WD Li, FR Lei, XQ Li - Journal Of Cellular And …, 2018 - Wiley Online Library
Micro RNA s (mi RNA s) are small non‐coding RNA s that regulate gene expression at a
post‐transcriptional level via either the degradation or translational repression of a target …

More than just a monolayer: the multifaceted role of endothelial cells in the pathophysiology of atherosclerosis

M Mussbacher, K Schossleitner… - Current atherosclerosis …, 2022 - Springer
Abstract Purpose of the Review In this review, we summarize current insights into the
versatile roles of endothelial cells in atherogenesis. Recent Findings The vascular …

Cardiovascular exosomes and MicroRNAs in cardiovascular physiology and pathophysiology

RJ Henning - Journal of cardiovascular translational research, 2021 - Springer
Cardiac exosomes mediate cell-to-cell communication, stimulate or inhibit the activities of
target cells, and affect myocardial hypertrophy, injury and infarction, ventricular remodeling …

The impact of adipose tissue–derived miRNAs in metabolic syndrome, obesity, and cancer

GS Heyn, LH Corrêa, KG Magalhães - Frontiers in endocrinology, 2020 - frontiersin.org
Obesity is a multifactorial and complex condition that is characterized by abnormal and
excessive white adipose tissue accumulation, which can lead to the development of …

Potential value of miR-221/222 as diagnostic, prognostic, and therapeutic biomarkers for diseases

J Song, Y Ouyang, J Che, X Li, Y Zhao, K Yang… - Frontiers in …, 2017 - frontiersin.org
microRNAs (miRNAs) are short non-coding RNAs that regulate gene expression by base
pairing with their target messenger RNAs. Dysregulation of miRNAs is involved in the …

The role of miR-126 in embryonic angiogenesis, adult vascular homeostasis, and vascular repair and its alterations in atherosclerotic disease

DA Chistiakov, AN Orekhov, YV Bobryshev - Journal of molecular and …, 2016 - Elsevier
Abstract Expression of microRNA (miR)-126 is enriched in endothelial cells (ECs) and
endothelial progenitor cells (EPCs). MiR-126 is considered a master regulator of …

MSCs and their exosomes: a rapidly evolving approach in the context of cutaneous wounds therapy

F Marofi, KI Alexandrovna, R Margiana… - Stem Cell Research & …, 2021 - Springer
Currently, mesenchymal stem/stromal stem cell (MSC) therapy has become a promising
option for accelerating cutaneous wound healing. In vivo reports have outlined the robust …