Goods and bads of the endocannabinoid system as a therapeutic target: Lessons learned after 30 years
The cannabis derivative marijuana is the most widely used recreational drug in the Western
world and is consumed by an estimated 83 million individuals (∼ 3% of the world …
world and is consumed by an estimated 83 million individuals (∼ 3% of the world …
[HTML][HTML] The endocannabinoid system and PPARs: Focus on their signalling crosstalk, action and transcriptional regulation
FA Iannotti, RM Vitale - Cells, 2021 - mdpi.com
Peroxisome proliferator-activated receptors (PPARs) are a family of nuclear receptors
including PPARα, PPARγ, and PPARβ/δ, acting as transcription factors to regulate the …
including PPARα, PPARγ, and PPARβ/δ, acting as transcription factors to regulate the …
[HTML][HTML] Gut microbiota suppress feeding induced by palatable foods
J Ousey, JC Boktor, SK Mazmanian - Current Biology, 2023 - cell.com
Feeding behaviors depend on intrinsic and extrinsic factors including genetics, food
palatability, and the environment. 1, 2, 3, 4, 5 The gut microbiota is a major environmental …
palatability, and the environment. 1, 2, 3, 4, 5 The gut microbiota is a major environmental …
Targeting gut dysbiosis against inflammation and impaired autophagy in Duchenne muscular dystrophy
Nothing is known about the potential implication of gut microbiota in skeletal muscle
disorders. Here, we provide evidence that fecal microbiota composition along with …
disorders. Here, we provide evidence that fecal microbiota composition along with …
[HTML][HTML] The gut microbiome, endocannabinoids and metabolic disorders
FA Iannotti, V Di Marzo - Journal of Endocrinology, 2021 - joe.bioscientifica.com
Two complex systems are emerging as being deeply involved in the control of energy
metabolism. The intestinal microbiota, with its warehouse of genes, proteins and small …
metabolism. The intestinal microbiota, with its warehouse of genes, proteins and small …
Targeting the endocannabinoid system for the treatment of abdominal pain in irritable bowel syndrome
SM Brierley, B Greenwood-Van Meerveld… - Nature Reviews …, 2023 - nature.com
The management of visceral pain in patients with disorders of gut–brain interaction, notably
irritable bowel syndrome, presents a considerable clinical challenge, with few available …
irritable bowel syndrome, presents a considerable clinical challenge, with few available …
[HTML][HTML] Roles for the gut microbiota in regulating neuronal feeding circuits
BY Kristie, EY Hsiao - The Journal of clinical investigation, 2021 - Am Soc Clin Investig
The gut microbiota has the capacity to affect host appetite via intestinal satiety pathways, as
well as complex feeding behaviors. In this Review, we highlight recent evidence that the gut …
well as complex feeding behaviors. In this Review, we highlight recent evidence that the gut …
[HTML][HTML] Current knowledge of the implication of lipid mediators in psoriasis
The skin is an organ involved in several biological processes essential to the proper
functioning of the organism. One of these essential biological functions of the skin is its …
functioning of the organism. One of these essential biological functions of the skin is its …
[HTML][HTML] Gut microbes and food reward: from the gut to the brain
A de Wouters d'Oplinter, SJP Huwart, PD Cani… - Frontiers in …, 2022 - frontiersin.org
Inappropriate food intake behavior is one of the main drivers for fat mass development
leading to obesity. Importantly the gut microbiota-mediated signals have emerged as key …
leading to obesity. Importantly the gut microbiota-mediated signals have emerged as key …
[HTML][HTML] Gut microbiota and oleoylethanolamide in the regulation of intestinal homeostasis
C De Filippo, A Costa, MV Becagli… - Frontiers in …, 2023 - frontiersin.org
A vast literature strongly suggests that the endocannabinoid (eCB) system and related
bioactive lipids (the paracannabinoid system) contribute to numerous physiological …
bioactive lipids (the paracannabinoid system) contribute to numerous physiological …