The main goal of chemotherapeutic drugs is to induce massive cell death in tumors.
Cisplatin is an antitumor drug widely used to treat several types of cancer. Despite its …

DNA interstrand cross-links (ICLs) covalently connect the two strands of the double helix and
are extremely cytotoxic. Defective ICL repair causes the bone marrow failure and cancer …

Members of the human microbiota are increasingly being correlated to human health and
disease states, but the majority of the underlying microbial metabolites that regulate host …

Despite the widespread use of antineoplastic platinum drugs, a number of accompanying
disadvantages exist. In connection with attempts to circumvent these problems new platinum …

The replicative machinery encounters many impediments, some of which can be overcome
by lesion bypass or replication restart pathways, leaving repair for a later time. However …

DNA interstrand crosslinks (ICLs) formed by antitumor agents, such as cisplatin or mitomycin
C, are highly cytotoxic DNA lesions. Their repair is believed to be triggered primarily by the …

Y-Family DNA polymerases specialize in translesion synthesis, bypassing damaged bases
that would otherwise block the normal progression of replication forks. Y-Family …

Cisplatin-based chemotherapeutic regimens are the most frequently used (neo) adjuvant
treatments for the majority of solid tumors. While platinum-based chemotherapeutic …

Nitrosamines occur widespread in food, drinking water, cosmetics, as well as tobacco smoke
and can arise endogenously. More recently, nitrosamines have been detected as impurities …

DNA interstrand cross-links (ICLs) prevent strand separation during DNA replication and
transcription and therefore are extremely cytotoxic. In metazoans, a major pathway of ICL …