The intertwined roles of oxidative stress and endoplasmic reticulum stress in glaucoma

DJ Hurley, C Normile, M Irnaten, C O'Brien - Antioxidants, 2022 - mdpi.com
Glaucoma is the leading cause of irreversible blindness worldwide, and the burden of the
disease continues to grow as the global population ages. Currently, the only treatment …

Clinical pharmacology and pharmacogenetics of prostaglandin analogues in glaucoma

L Zhou, W Zhan, X Wei - Frontiers in Pharmacology, 2022 - frontiersin.org
Glaucoma is the main cause of irreversible visual loss worldwide, and comprises a group of
progressive, age-related, and chronic optic neuropathies. Prostaglandin analogs are …

[HTML][HTML] Pathologically high intraocular pressure induces mitochondrial dysfunction through Drp1 and leads to retinal ganglion cell PANoptosis in glaucoma

Z Zeng, M You, C Fan, R Rong, H Li, X Xia - Redox Biology, 2023 - Elsevier
Glaucoma is a common neurodegenerative disease characterized by progressive retinal
ganglion cell (RGC) loss and visual field defects. Pathologically high intraocular pressure …

[HTML][HTML] Open angle glaucoma

N Mahabadi, LA Foris, K Tripathy - 2017 - europepmc.org
Objectives: Identify the risk factors for open-angle glaucoma. Explain how to diagnose open-
angle glaucoma. Summarize the treatment options available for patients with open-angle …

Relationship between high dose intake of vitamin B12 and glaucoma: Evidence from NHANES 2005–2008 among United States adults

Z Liu, Y Hu, Y Wang, B Xu, J Zhao, Z Yu - Frontiers in Nutrition, 2023 - frontiersin.org
Objective Glaucoma has currently become the second leading cause of blindness in the
world. Serum vitamin B12 level has been found to be involved in the development and …

Label-free detection and classification of glaucoma based on drop-coating deposition Raman spectroscopy

Y Li, H Lin, Q He, C Zuo, M Lin, T Xu - Applied Sciences, 2023 - mdpi.com
Featured Application This study was the first to use drop-coating deposition Raman
spectroscopy (DCDRS) for the tear-based detection of glaucoma, including primary open …

Modeling complex age-related eye disease

S Becker, Z L'Ecuyer, BW Jones, MA Zouache… - Progress in Retinal and …, 2024 - Elsevier
Modeling complex eye diseases like age-related macular degeneration (AMD) and
glaucoma poses significant challenges, since these conditions depend highly on age …

Functional role of translocator protein and its ligands in ocular diseases

M Yu, S Zhao - Molecular Medicine Reports, 2024 - spandidos-publications.com
The 18 kDa translocator protein (TSPO) is an essential outer mitochondrial membrane
protein that is responsible for mitochondrial transport, maintenance of mitochondrial …

[HTML][HTML] Recent overviews on the drug delivery aspects and applications of brinzolamide for the management of glaucoma

Y Sharma, K Chahar, L Mishra, L Kumari, A Singla… - Health Sciences …, 2023 - Elsevier
Brinzolamide (BRZ) is a highly selective carbonic anhydrase (CA) inhibitor which leads to
decreases intraocular pressure (IOP) by slowing down the production of aqueous humour. It …

Lack of Association of Polymorphism Located Upstream of ABCA1 (rs2472493), in FNDC3B (rs7636836), and Near ANKRD55MAP3K1 Genes (rs61275591) in …

AA Kondkar, T Sultan, TA Azad, EA Osman… - Genes, 2023 - mdpi.com
Polymorphisms rs2472493 near ABCA1, rs7636836 in FNDC3B, and rs61275591 near the
ANKRD55–MAP3K1 genes were previously reported to exhibit genome-wide significance in …