[HTML][HTML] Proactive monitoring of anti-TNF agents improves follow-up of paediatric patients with Crohn disease

BR Azor, R Martín-Masot, AD Khialani… - Anales de Pediatría …, 2023 - Elsevier
Introduction and aims The incidence of paediatric inflammatory bowel disease has
increased in recent decades. The aim of the present study was to evaluate the role of …

[HTML][HTML] Preemptive dose optimization using therapeutic drug monitoring for biologic therapy of Crohn's disease: avoiding failure while lowering costs?

N Vande Casteele, A Gils - Digestive Diseases and Sciences, 2015 - Springer
Crohn's disease is associated with a high economic burden to society due to healthcare
costs and productivity losses, of which, before the introduction of antitumor necrosis factor …

Pharmacokinetic modeling and simulation of biologicals in inflammatory bowel disease: the dawning of a new era for personalized treatment

E Dreesen, A Gils, S Vermeire - Current drug targets, 2018 - ingentaconnect.com
Background: Anti-tumor necrosis factor-alpha and anti-integrin monoclonal antibodies show
great benefits for inducing and maintaining remission, healing the mucosa and restoring the …

Out-of-pocket cost is a barrier to therapeutic drug monitoring in inflammatory bowel disease

JP Campbell, E Burton, S Wymer, M Shaw… - Digestive diseases and …, 2017 - Springer
Background Therapeutic drug monitoring (TDM) is increasingly performed to optimize
biologic therapy in inflammatory bowel disease (IBD). However, patients and physicians …

[HTML][HTML] The effect of early Trough level of infliximab on subsequent disease course in patients with Crohn disease: a prospective cohort study

N Ishida, T Miyazu, T Sugiyama, S Tamura, T Kagami… - Medicine, 2020 - journals.lww.com
The effect of early trough level of infliximab on subsequent... : Medicine The effect of early trough
level of infliximab on subsequent disease course in patients with Crohn disease: A prospective …

A value proposition for trough level-based anti-TNFα drug dosing

V Scharnhorst, EMH Schmitz, D van de Kerkhof… - Clinica Chimica …, 2019 - Elsevier
Abstract Treatment of inflammatory bowel diseases and rheumatic disorders with anti-tumor
necrosis factor alpha (TNFα) drugs is expensive, while a significant proportion of patients …

Therapeutic drug monitoring is more cost-effective than a clinically based approach in the management of loss of response to infliximab in inflammatory bowel disease …

H Yanai, I Dotan - Journal of Crohn's and Colitis, 2019 - academic.oup.com
Inflammatory bowel disease [IBD] consists of chronic conditions that carry a large economic
burden worldwide. This economic burden has many drivers, including the cost and …

Emerging therapeutic targets and strategies in Crohn's disease

F Furfaro, G Fiorino, M Allocca, D Gilardi… - Expert Review of …, 2016 - Taylor & Francis
Crohn's disease (CD) is an immune-mediated inflammatory bowel disease, in which
inflammation is driven by a complex interaction between the microbiota, immune cells …

[HTML][HTML] La monitorización proactiva de niveles de anti-TNF mejora el seguimiento de los pacientes pediátricos con enfermedad de Crohn

BR Azor, R Martín-Masot, AD Khialani… - Anales de …, 2023 - Elsevier
Introducción y objetivos La incidencia de la enfermedad inflamatoria intestinal pediátrica ha
aumentado en las últimas décadas. El objetivo del presente estudio fue evaluar el papel de …

Optimization of biologic therapy in Crohn's disease

M Razvi, M Lazarev - Expert Opinion on Biological Therapy, 2018 - Taylor & Francis
Introduction: Crohn's disease (CD) is a manifestation of inflammatory bowel disease (IBD),
which can result in significant morbidity. Biologic therapy with anti-TNF medication has been …