IgA nephropathy

E Stamellou, C Seikrit, SCW Tang, P Boor… - Nature Reviews …, 2023 - nature.com
IgA nephropathy (IgAN), the most prevalent primary glomerulonephritis worldwide, carries a
considerable lifetime risk of kidney failure. Clinical manifestations of IgAN vary from …

IgA nephropathy: current understanding and perspectives on pathogenesis and targeted treatment

Y Du, T Cheng, C Liu, T Zhu, C Guo, S Li, X Rao, J Li - Diagnostics, 2023 - mdpi.com
Immunoglobulin A nephropathy (IgAN) is the most common primary glomerulonephritis
worldwide, with varied clinical and histopathological features between individuals …

IgA nephropathy in adults—treatment standard

PJ Gleeson, MM O'Shaughnessy… - Nephrology Dialysis …, 2023 - academic.oup.com
Immunoglobulin A nephropathy (IgAN) is the most common primary form of glomerular
disease worldwide and carries a high lifetime risk of kidney failure. The underlying …

Treatment of IgA nephropathy: a rapidly evolving field

K El Karoui, FC Fervenza… - Journal of the American …, 2024 - journals.lww.com
The pivotal event in the pathophysiology of IgA nephropathy is the binding of circulating IgA-
containing immune complexes to mesangial cells, with secondary glomerular and …

The treatment of primary IgA nephropathy: change, change, change

DJ Caster, RA Lafayette - American Journal of Kidney Diseases, 2023 - Elsevier
IgA nephropathy (IgAN) is the most common glomerular disease in the world. However, the
approach to treatment remains controversial. There has been an explosion of clinical trials …

KDOQI US commentary on the 2021 KDIGO clinical practice guideline for the management of glomerular diseases

LH Beck Jr, I Ayoub, D Caster, MJ Choi, J Cobb… - American Journal of …, 2023 - Elsevier
The KDIGO 2021 Clinical Practice Guideline for the Management of Glomerular Diseases
represents the first update to this set of recommendations since the initial set of KDIGO …

Crescents and IgA nephropathy: a delicate marriage

H Trimarchi, M Haas, R Coppo - Journal of Clinical Medicine, 2022 - mdpi.com
IgA nephropathy (IgAN) is a progressive disease with great variability in the clinical course.
Among the clinical and pathologic features contributing to variable outcomes, the presence …

Assessing prognosis in IgA nephropathy

J Floege, S Wied, T Rauen - Kidney international, 2022 - Elsevier
Assessing the prognosis is essential in chronic diseases, such as IgA nephropathy. The
2021 Kidney Disease: Improving Global Outcomes (KDIGO) guidelines recommend the …

Systematic review of the Oxford Classification of IgA nephropathy: reproducibility and prognostic value

AJ Howie, AD Lalayiannis - Kidney360, 2023 - journals.lww.com
Background The Oxford classification of IgA nephropathy defined five prognostic features
scored subjectively in renal biopsies: mesangial cellularity (M), endocapillary …

Use of histologic parameters to predict glomerular disease progression: findings from the China kidney biopsy cohort study

X Zhang, F Luo, R Chen, J Shen, X Liu, Y Shi… - American Journal of …, 2023 - Elsevier
Rationale & Objective Challenges in achieving valid risk prediction and stratification impede
treatment decisions and clinical research design for patients with glomerular diseases. This …