Spinal cord injury (SCI) leads to loss of motor and sensory function below the injury level
and imposes a considerable burden on patients, families, and society. Repair of the injured …

Spinal cord injury remains a scientific and therapeutic challenge with great cost to
individuals and society. The goal of research in this field is to find a means of restoring lost …

In the hippocampus GABAergic local circuit inhibitory interneurons represent only~ 10–15%
of the total neuronal population; however, their remarkable anatomical and physiological …

How neural circuits develop in the human brain has remained almost impossible to study at
the neuronal level. Here, we investigate human cortical neuron development, plasticity, and …

Background Spinal cord injury (SCI) is a debilitating medical condition that can result in the
irreversible loss of sensorimotor function. Current therapies fail to provide an effective …

While rapid advancements in regenerative medicine strategies for spinal cord injury (SCI)
have been made, most research in this field has focused on the early stages of incomplete …

Organoids represent one of the most important advancements in the field of stem cells
during the past decade. They are three-dimensional in vitro culturing models that originate …

Transplantation of neural stem/progenitor cells (NS/PCs) derived from human induced
pluripotent stem cells (hiPSCs) is considered to be a promising therapy for spinal cord injury …

Spinal interneurons are important facilitators and modulators of motor, sensory, and
autonomic functions in the intact CNS. This heterogeneous population of neurons is now …

Despite substantial efforts dedicated to the development of new, nonaddictive analgesics,
success in treating pain has been limited. Clinically available analgesic agents generally …