Protein posttranslational modifications (PTMs) refer to the breaking or generation of covalent
bonds on the backbones or amino acid side chains of proteins and expand the diversity of …

The metabolism of glucose and lipids is essential for energy production in the body, and
dysregulation of the metabolic pathways of these molecules is implicated in various acute …

The COVID-19 is an infectious disease caused by SARS-CoV-2 infection. A large number of
clinical studies found high-level expression of pro-inflammatory cytokines in patients …

Lymph node (LN) metastasis is one of the predominant metastatic routes of non-small cell
lung cancer (NSCLC) and is considered as a leading cause for the unsatisfactory prognosis …

Post-translational modification by Small Ubiquitin-like Modifier (SUMO) proteins regulates
numerous cellular processes. This modification involves the covalent and reversible …

Lymph node (LN) metastasis occurs frequently in pancreatic ductal adenocarcinoma
(PDAC) and predicts poor prognosis for patients. The KRASG12D mutation confers an …

Stimulator of interferon genes (STING) is an endoplasmic-reticulum resident protein, playing
essential roles in immune responses against microbial infections. However, over-activation …

Mitochondria have many forms and can change their shape through fusion and fission of the
outer and inner membranes, called “mitochondrial dynamics”. Mitochondrial outer …

Glioma is the most common malignant tumor of the central nervous system in adults. The
tumor microenvironment (TME) is related to poor prognosis in glioma patients. Glioma cells …

One major role of the eukaryotic peptidic post-translational modifier SUMO in the cell is
transcriptional control. This occurs via modification of virtually all classes of transcriptional …