MYB oncoproteins: emerging players and potential therapeutic targets in human cancer
Y Cicirò, A Sala - Oncogenesis, 2021 - nature.com
MYB transcription factors are highly conserved from plants to vertebrates, indicating that
their functions embrace fundamental mechanisms in the biology of cells and organisms. In …
their functions embrace fundamental mechanisms in the biology of cells and organisms. In …
[HTML][HTML] Myb proteins: angels and demons in normal and transformed cells
Y Zhou, SA Ness - Frontiers in bioscience: a journal and virtual …, 2011 - ncbi.nlm.nih.gov
A key regulator of proliferation, differentiation and cell fate, the c-Myb transcription factor
regulates the expression of hundreds of genes and is in turn regulated by numerous …
regulates the expression of hundreds of genes and is in turn regulated by numerous …
Recurrent Fusions in MYB and MYBL1 Define a Common, Transcription Factor–Driven Oncogenic Pathway in Salivary Gland Adenoid Cystic Carcinoma
Adenoid cystic carcinoma (ACC), the second most common malignancy of salivary glands, is
a rare tumor with a bleak prognosis for which therapeutic targets are unavailable. We used …
a rare tumor with a bleak prognosis for which therapeutic targets are unavailable. We used …
Situational awareness: regulation of the myb transcription factor in differentiation, the cell cycle and oncogenesis
OL George, SA Ness - Cancers, 2014 - mdpi.com
This review summarizes the mechanisms that control the activity of the c-Myb transcription
factor in normal cells and tumors, and discusses how c-Myb plays a role in the regulation of …
factor in normal cells and tumors, and discusses how c-Myb plays a role in the regulation of …
From modulation of cellular plasticity to potentiation of therapeutic resistance: new and emerging roles of MYB transcription factors in human malignancies
MYB transcription factors are encoded by a large family of highly conserved genes from
plants to vertebrates. There are three members of the MYB gene family in human, namely …
plants to vertebrates. There are three members of the MYB gene family in human, namely …
Distinct changes in gene expression induced by A-Myb, B-Myb and c-Myb proteins
Abstract The c-Myb, A-Myb and B-Myb transcription factors have nearly identical DNA-
binding domains, activate the same reporter gene constructs in animal cells, but have …
binding domains, activate the same reporter gene constructs in animal cells, but have …
Structure and function of MuvB complexes
Proper progression through the cell-division cycle is critical to normal development and
homeostasis and is necessarily misregulated in cancer. The key to cell-cycle regulation is …
homeostasis and is necessarily misregulated in cancer. The key to cell-cycle regulation is …
Alternative RNA splicing produces multiple forms of c-Myb with unique transcriptional activities
JP O'Rourke, SA Ness - Molecular and cellular biology, 2008 - Am Soc Microbiol
The c-Myb transcription factor regulates the proliferation and differentiation of hematopoietic
cells, and activated alleles of c-myb induce leukemias and lymphomas in animals. Relatively …
cells, and activated alleles of c-myb induce leukemias and lymphomas in animals. Relatively …
B-myb and C-myb play required roles in neuronal apoptosis evoked by nerve growth factor deprivation and DNA damage
Activation of cell cycle elements plays a required role in neuronal apoptosis associated with
both development and neurodegenerative disorders. We demonstrated previously that …
both development and neurodegenerative disorders. We demonstrated previously that …
Myb protein specificity: evidence of a context-specific transcription factor code
SA Ness - Blood Cells, Molecules, and Diseases, 2003 - Elsevier
Vertebrates express three different Myb family transcription factors, A-Myb, B-Myb, and c-
Myb, that share a highly conserved DNA binding domain, bind to the same DNA sequences …
Myb, that share a highly conserved DNA binding domain, bind to the same DNA sequences …