Immune dysregulation is an important component of the pathophysiology of COVID-19. A
large body of literature has reported the effect of immune-based therapies in patients with …

The human innate and adaptive immune systems consist of effector cells producing
cytokines (interleukins, interferons, chemokines, and numerous other mediators). Usually, a …

The neuroanatomical basis behind acupuncture practice is still poorly understood. Here, we
used intersectional genetic strategy to ablate NPY+ noradrenergic neurons and/or adrenal …

Importance Definitions of sepsis and septic shock were last revised in 2001. Considerable
advances have since been made into the pathobiology (changes in organ function …

Sepsis is a leading cause of death in critical illness, and its pathophysiology varies
depending on preexisting medical conditions. Here we identified nonalcoholic fatty liver …

Sepsis is a life-threatening clinical condition caused by a dysregulated host response to
infection. Sepsis-associated encephalopathy (SAE) is a common but poorly understood …

Background Subphenotypes have been identified within heterogeneous diseases such as
asthma and breast cancer, with important therapeutic implications. We assessed whether …

Sepsis is a disease caused by infection, which is characterized by a dysregulated immune
response in the host and affects more than 30 million people worldwide each year …

Preclinical models of human disease provide powerful tools for therapeutic discovery but
have limitations. This problem is especially apparent in the field of acute kidney injury (AKI) …

Sepsis, a clinical syndrome occurring in patients following infection or injury, is a leading
cause of morbidity and mortality worldwide. Current immunological mechanisms do not …