Genes, genetics, and environment in type 2 diabetes: implication in personalized medicine

N Kaul, S Ali - DNA and Cell Biology, 2016 - liebertpub.com
Type 2 diabetes (T2D) is a multifactorial anomaly involving 57 genes located on 16 different
chromosomes and 136 single nucleotide polymorphisms (SNPs). Ten genes are located on …

[HTML][HTML] Genetic variants and their associations to type 2 diabetes mellitus complications in The United Arab Emirates

S ElHajj Chehadeh, NS Sayed… - Frontiers in …, 2022 - frontiersin.org
Aim Type 2 Diabetes Mellitus (T2DM) is associated with microvascular complications,
including diabetic retinopathy (DR), diabetic nephropathy (DNp), and diabetic peripheral …

Variants in the RARRES2 gene are associated with serum chemerin and increase the risk of diabetic kidney disease in type 2 diabetes

K Zhao, W Ding, Y Zhang, K Ma, D Wang, C Hu… - International Journal of …, 2020 - Elsevier
Genetic susceptibility plays an important role in the pathogenesis of diabetic kidney disease
(DKD). Recent studies have suggested that chemerin (encoded by the RARRES2 gene) is a …

[HTML][HTML] Interaction between a diabetes-related methylation site (TXNIP cg19693031) and variant (GLUT1 rs841853) on fasting blood glucose levels among non …

HH Tsai, CY Shen, CC Ho, SY Hsu, DM Tantoh… - Journal of Translational …, 2022 - Springer
Background Type 2 diabetes mellitus (T2DM) is caused by a combination of environmental,
genetic, and epigenetic factors including, fasting blood glucose (FBG), genetic variant …

The contribution of genetic variants of SLC2A1 gene in T2DM and T2DM-nephropathy: association study and meta-analysis

I Stefanidis, M Tziastoudi, EE Tsironi, E Dardiotis… - Renal failure, 2018 - Taylor & Francis
An association study was conducted to investigate the relation between 14 variants of
glucose transporter 1 gene (SLC2A1) and the risk of type 2 diabetes (T2DM) leading to …

Association of rs10830963 MTNR1B and rs841853 SLC2A1 polymorphism with obesity on type 2 diabetes patients: an overview of melatonin receptor and transporter

Y Tursinawati, A Kartikadewi… - The Indonesian …, 2021 - inabj.tjahajabaroe.com
BACKGROUND: One of the hormones that plays a role in glucose metabolism of Type 2
Diabetes Mellitus (T2DM) is melatonin. Its genetic variation is believed to play a significant …

[PDF][PDF] Genetic and environmental predictors of chronic kidney disease in patients with type 2 diabetes and diabetic foot ulcer: a pilot study

B Mrozikiewicz-Rakowska, P Maroszek… - J Physiol …, 2015 - jpp.krakow.pl
Chronic kidney disease (CKD) is often observed among patients with type 2 diabetes
mellitus (T2DM) and diabetic foot (DF) leading to end stage renal disease. The aim of this …

Association of HaeIII single nucleotide polymorphisms in the SLC2A1 gene with risk of diabetic nephropathy; evidence from Kurdish patients with type 2 diabetes …

S Amini, M Javanmardi, A Mokarizadeh… - … Journal of Medicine, 2016 - academic.oup.com
Aims: Given the growing rate of patients with type 2 diabetes mellitus, uncovering the effects
of gene polymorphism on diabetes pathogenesis has attracted a lot of attention. Because …

Effect of transporter and DNA repair gene polymorphisms to lung cancer chemotherapy toxicity

J Chen, L Wu, Y Wang, J Yin, X Li, Z Wang, H Li, T Zou… - Tumor Biology, 2016 - Springer
Lung cancer is the first leading cause of cancer deaths. Chemotherapy toxicity is one of
factors that limited the efficacy of platinum-based chemotherapy in lung cancer patients …

[HTML][HTML] Altered expression of striatin‑4 is associated with poor prognosis in bladder transitional cell carcinoma

Y Zhang, X Gu, F Jiang, P Sun, X Li - Oncology Letters, 2021 - spandidos-publications.com
Abstract Striatin‑4 (STRN4 or Zinedin) is a scaffolding protein belonging to the mammalian
STRN family of proteins and consists of multiple functional signaling domains. Due to its …