Obesity is a major risk factor for metabolic disease, with white adipose tissue (WAT)
inflammation emerging as a key underlying pathology. Alongside its major role in energy …

Microsomal triglyceride transfer protein (MTP) was first identified as a major cellular protein
capable of transferring neutral lipids between membrane vesicles. Its role as an essential …

Interest in MHC-E–restricted CD8+ T cell responses has been aroused by the discovery of
their efficacy in controlling simian immunodeficiency virus (SIV) infection in a vaccine model …

Psoriasis is a chronic inflammatory skin disease associated with a T helper 17 response.
Yet, it has proved challenging to identify relevant peptide-based T cell antigens. Antigen …

Invariant natural killer T (iNKT) cells are evolutionarily conserved innate T cells that
influence inflammatory responses. We have shown that iNKT cells, previously thought to be …

Invariant NKT (iNKT) cells recognize lipid antigens presented by CD1d and respond rapidly
by killing tumor cells and release cytokines that activate and regulate adaptive immune …

The potential of mean force (PMF) of a phospholipid in a bilayer is a key thermodynamic
property that describes the energetic cost of localized lipid defects. We have calculated the …

Lipids play important roles in cellular dysfunction leading to disease. Although a major role
for phospholipids is in defining the membrane permeability barrier, phospholipids play a …

CD1 molecules are glycoproteins that present lipid antigens at the cell surface for
immunological recognition by specialized populations of T lymphocytes. Prior experimental …

Innate immune receptors play a key role in the early recognition of invading bacterial
pathogens and initiate the crucial innate immune response. The diverse macrophage …