Microfluidic separation, detection, and engineering of extracellular vesicles for cancer diagnostics and drug delivery

F Tian, C Liu, J Deng, J Sun - Accounts of Materials Research, 2022 - ACS Publications
Conspectus Extracellular vesicles (EVs) are cell-derived submicron bioparticles composed
of lipid bilayer membrane and molecular cargos, acting as important mediators of …

A Magnetically Driven Tandem Chip Enables Rapid Isolation and Multiplexed Profiling of Extracellular Vesicles

G Zhang, Y Wang, W Zhou, Y Lei, J Lu… - Angewandte …, 2023 - Wiley Online Library
The protein phenotypes of extracellular vesicles (EVs) have emerged as promising
biomarkers for cancer diagnosis and treatment monitoring. However, the technical …

Recent progress of exosome isolation and peptide recognition-guided strategies for exosome research

K Xu, Y Jin, Y Li, Y Huang, R Zhao - Frontiers in Chemistry, 2022 - frontiersin.org
Exosomes are membrane extracellular vesicles secreted by almost all kinds of cells, which
are rich in proteins, lipids, and nucleic acids. As a medium of intercellular communication …

Real-Time Monitoring of Exosomes Secretion from Single Cell Using Dual-Nanopore Biosensors

H Zhang, X Zheng, T Zhao, Y Chen, Y Luo, Y Dong… - ACS …, 2023 - ACS Publications
Exosomes secreted from cells carry rich information from their parent cells, representing a
promising biomarker for investigation of diseases. We develop a dual-nanopore biosensor …

Aptamer‐based extracellular vesicle isolation, analysis and therapeutics

L Zhu, W Tian, L Yuan, C Chi, Y Wang… - Interdisciplinary …, 2023 - Wiley Online Library
Extracellular vesicles (EVs) play an important role in many physiological processes. Thus,
EV analysis has a great value for the understanding of mechanisms underlying disease …

Application of Single Extracellular Vesicle Analysis Techniques

J Zhu, F Wu, C Li, J Mao, Y Wang, X Zhou… - International Journal …, 2023 - Taylor & Francis
Extracellular vesicles (EVs) are lipid containers that are actively released by cells and
contain complex molecular cargoes. These cargoes include abundant material such as …

Merging microfluidics with luminescence immunoassays for urgent point-of-care diagnostics of COVID-19

H Yuan, P Chen, C Wan, Y Li, BF Liu - TrAC Trends in Analytical Chemistry, 2022 - Elsevier
Abstract The Coronavirus disease 2019 (COVID-19) outbreak has urged the establishment
of a global-wide rapid diagnostic system. Current widely-used tests for COVID-19 include …

Advanced technologies for molecular diagnosis of cancer: State of pre-clinical tumor-derived exosome liquid biopsies

L Li, L Zhang, KC Montgomery, L Jiang, CJ Lyon… - Materials Today Bio, 2023 - Elsevier
Exosomes are membrane-defined extracellular vesicles (EVs) approximately 40–160​ nm
in diameter that are found in all body fluids including blood, urine, and saliva. They act as …

pH-mediated clustering of exosomes: breaking through the size limit of exosome analysis in conventional flow cytometry

X Liu, Z Zong, M Xing, X Liu, J Li, D Liu - Nano Letters, 2021 - ACS Publications
Exosomes have recently emerged as some of the most promising biomarkers for disease
diagnosis. Due to their small sizes and composition heterogeneity, exosomes are difficult to …

Point‐Of‐Care Ultra‐Portable Single‐Molecule Bioassays for One‐Health

E Macchia, F Torricelli, M Caputo, L Sarcina… - Advanced …, 2024 - Wiley Online Library
Screening asymptomatic organisms (humans, animals, plants) with a high‐diagnostic
accuracy using point‐of‐care‐testing (POCT) technologies, though still visionary holds great …