Worldwide, more than 7 million children have now been born after ART: these delivery rates
are steadily rising and now comprise 2–6% of births in the European countries. To achieve …

This monograph, written by the pioneers of IVF and reproductive medicine, celebrates the
history, achievements, and medical advancements made over the last 40 years in this …

Oxidative stress (OS) due to an imbalance between reactive oxygen species (ROS) and
antioxidants has been established as an important factor that can negatively affect the …

BACKGROUND A normal chromosomal constitution defined through PGT-A assessing all
chromosomes on trophectoderm (TE) biopsies represents the strongest predictor of embryo …

Advanced maternal age (AMA;> 35 year) is associated with a decline in both ovarian
reserve and oocyte competence. At present, no remedies are available to counteract the …

With the worldwide move towards single embryo transfer there has been a renewed focus
on the requirement for reliable means of assessing embryo viability. In an era of …

BACKGROUND Despite advances in ART, implantation and pregnancy rates per embryo
transfer still remain low. IVF laboratories strive to ensure that the process of handling …

SUMMARY ANSWER: The present ESHRE document provides 11 recommendations on
how to introduce TLT in the IVF laboratory. WHAT IS KNOWN ALREADY: Studies have been …

Cryopreservation has become a central pillar in assisted reproduction, reflected in the
exponential increase of “freeze all” cycles in the past few years. Vitrification makes it …

STUDY QUESTION What is the effect of a combination of three antioxidants (Acetyl-L-
Carnitine, N-Acetyl-L-Cysteine and α-Lipoic Acid), present in IVF medium during mouse …