Tryptophan is an essential amino acid critical for protein synthesis in humans that has
emerged as a key player in the microbiota-gut-brain axis. It is the only precursor for the …

Early adversity is a key risk factor for the development of several psychiatric disorders,
including anxiety and depression. During early life, neurocircuits that regulate emotionality …

Maternal separation in early life has a detrimental effect on the physiological and
biochemical functions of the brains of offspring and can lead to anxiety-and depression-like …

Glutamate and GABA signaling systems are necessary to maintain proper function of the
central nervous system through excitation/inhibition (E/I) balance. Alteration of this balance …

Early life stress (ELS) in developing children has been linked to physical and psychological
sequelae in adulthood. In the present study, we investigated the effects of ELS on brain and …

Synaptic plasticity is one of the putative mechanisms involved in the maturation of the
prefrontal cortex (PFC) during postnatal development. Early life stress (ELS) affects the …

Abstract A Density Functional Theory analysis was performed to investigate the relationships
between 5HT1A receptor affinity and of group of 4-butyl-arylpiperazine-3-(1H-indol-3-yl) …

Synaptic plasticity constitutes a fundamental process in the reorganization of neural
networks that underlie memory, cognition, emotional responses, and behavioral planning. At …

Amygdala is the central brain region governing emotional responses of mammals. However,
the detailed molecular taxonomy of amygdala in higher mammals such as primates is still …

Rationale Early-life maternal separation can lead to anxiety-like and depression-like
behaviors in mice reared under maternal separation conditions. Scopoletin, a compound …