Mass spectrometry-based metabolomics: a guide for annotation, quantification and best reporting practices

S Alseekh, A Aharoni, Y Brotman, K Contrepois… - Nature …, 2021 - nature.com
Mass spectrometry-based metabolomics approaches can enable detection and
quantification of many thousands of metabolite features simultaneously. However …

Metabolic pathway analysis using stable isotopes in patients with cancer

CR Bartman, B Faubert, JD Rabinowitz… - Nature Reviews …, 2023 - nature.com
Metabolic reprogramming is central to malignant transformation and cancer cell growth. How
tumours use nutrients and the relative rates of reprogrammed pathways are areas of intense …

Toward merging untargeted and targeted methods in mass spectrometry-based metabolomics and lipidomics

T Cajka, O Fiehn - Analytical chemistry, 2016 - ACS Publications
Advances in mass spectrometry (MS) and data processing have led to discoveries in
regulation of cellular metabolism by using metabolomics and lipidomics approaches. 1, 2 …

Metabolomics toward personalized medicine

M Jacob, AL Lopata, M Dasouki… - Mass spectrometry …, 2019 - Wiley Online Library
Metabolomics, which is the metabolites profiling in biological matrices, is a key tool for
biomarker discovery and personalized medicine and has great potential to elucidate the …

The strengths and weaknesses of NMR spectroscopy and mass spectrometry with particular focus on metabolomics research

AHM Emwas - Metabonomics: Methods and protocols, 2015 - Springer
Mass spectrometry (MS) and nuclear magnetic resonance (NMR) have evolved as the most
common techniques in metabolomics studies, and each brings its own advantages and …

Metabolite measurement: pitfalls to avoid and practices to follow

W Lu, X Su, MS Klein, IA Lewis, O Fiehn… - Annual review of …, 2017 - annualreviews.org
Metabolites are the small biological molecules involved in energy conversion and
biosynthesis. Studying metabolism is inherently challenging due to metabolites' reactivity …

Advances in mass spectrometry-based metabolomics for investigation of metabolites

JL Ren, AH Zhang, L Kong, XJ Wang - RSC advances, 2018 - pubs.rsc.org
Metabolomics is the systematic study of all the metabolites present within a biological
system, which consists of a mass of molecules, having a variety of physical and chemical …

Development of a plasma pseudotargeted metabolomics method based on ultra-high-performance liquid chromatography–mass spectrometry

F Zheng, X Zhao, Z Zeng, L Wang, W Lv, Q Wang… - Nature protocols, 2020 - nature.com
Untargeted methods are typically used in the detection and discovery of small organic
compounds in metabolomics research, and ultra-high-performance liquid chromatography …

Wild relatives of maize, rice, cotton, and soybean: treasure troves for tolerance to biotic and abiotic stresses

J Mammadov, R Buyyarapu, SK Guttikonda… - Frontiers in plant …, 2018 - frontiersin.org
Global food demand is expected to nearly double by 2050 due to an increase in the world's
population. The Green Revolution has played a key role in the past century by increasing …

Data analysis strategies for targeted and untargeted LC-MS metabolomic studies: Overview and workflow

E Gorrochategui, J Jaumot, S Lacorte… - TrAC Trends in Analytical …, 2016 - Elsevier
Data analysis is a very challenging task in LC-MS metabolomic studies. The use of powerful
analytical techniques (eg, high-resolution mass spectrometry) provides high-dimensional …