PCR-based techniques for leprosy diagnosis: from the laboratory to the clinic

AN Martinez, C Talhari, MO Moraes… - PLoS Neglected …, 2014 - journals.plos.org
In leprosy, classic diagnostic tools based on bacillary counts and histopathology have been
facing hurdles, especially in distinguishing latent infection from active disease and …

In search of biomarkers for leprosy by unraveling the host immune response to Mycobacterium leprae

A van Hooij, A Geluk - Immunological Reviews, 2021 - Wiley Online Library
Mycobacterium leprae, the causative agent of leprosy, is still actively transmitted in endemic
areas reflected by the fairly stable number of new cases detected each year. Recognizing …

Mycobacterium leprae–host-cell interactions and genetic determinants in leprosy: an overview

RO Pinheiro, J de Souza Salles, EN Sarno… - Future …, 2011 - Future Medicine
Leprosy, also known as Hansen's disease, is a chronic infectious disease caused by
Mycobacterium leprae in which susceptibility to the mycobacteria and its clinical …

Risk and protective factors for leprosy development determined by epidemiological surveillance of household contacts

IMB Goulart, DO Bernardes Souza… - Clinical and vaccine …, 2008 - Am Soc Microbiol
Household contacts of leprosy patients are the group with the highest risk of developing the
disease, and although many risk or prevention factors have been identified, they have not …

Leprosy: diagnostic and control challenges for a worldwide disease

IMB Goulart, LR Goulart - Archives of dermatological research, 2008 - Springer
Leprosy is a curable disease with well-defined etiology, but lacks better diagnostic tools,
preventive and therapeutic strategies. The continued application of the Ridley–Jopling …

New biomarkers with relevance to leprosy diagnosis applicable in areas hyperendemic for leprosy

A Geluk, K Bobosha… - The Journal of …, 2012 - journals.aai.org
Leprosy is not eradicable with currently available diagnostics or interventions, as evidenced
by its stable incidence. Early diagnosis of Mycobacterium leprae infection should therefore …

Epitope imprinting of Mycobacterium leprae bacteria via molecularly imprinted nanoparticles using multiple monomers approach

A Kushwaha, J Srivastava, AK Singh, R Anand… - Biosensors and …, 2019 - Elsevier
Mycobacterium leprae causes endemic disease leprosy which becomes chronic if not
treated timely. To expedite this 'timely diagnosis', and that also at an early stage, here an …

Analysis of Antibody Responses to Mycobacterium leprae Phenolic Glycolipid I, Lipoarabinomannan, and Recombinant Proteins To Define Disease Subtype-Specific …

JS Spencer, HJ Kim, WH Wheat… - Clinical and Vaccine …, 2011 - Am Soc Microbiol
ABSTRACT A simple serodiagnostic test based on the Mycobacterium leprae-specific
phenolic glycolipid I (PGL-I), for individuals with leprosy is nearly universally positive in …

Immunologically reactive M. leprae antigens with relevance to diagnosis and vaccine development

LH Sampaio, MMA Stefani, RM Oliveira… - BMC infectious …, 2011 - Springer
Background Leprosy is a chronic infectious disease caused by Mycobacterium leprae that
can manifest a wide variety of immunological and clinical outcomes ranging from potent …

Identification of serological biomarkers of infection, disease progression and treatment efficacy for leprosy

JS Spencer, MS Duthie, A Geluk… - Memórias do Instituto …, 2012 - SciELO Brasil
Although leprosy is curable with drug treatment, the identification of biomarkers of infection,
disease progression and treatment efficacy would greatly help to reduce the overall …